ZFIN

ZFIN ID: ZDB-GENE-040718-141

ZFIN ID: ZDB-GENE-040718-141

CITATIONS (89 total)

Gene Name:	opsin 1 (cone pigments), long-wave-sensitive, 2
Gene Symbol:	opn1lw2

Chen, R., Zhou, G., Jiao, X., Nelson, R.F., Connaughton, V.P., Dong, L., Perkins, B.D., Hejtmancik, J.F. (2026) miRNA 183 Knockout Alters Cone Subtype Distribution, Transcriptional Activity and ERG Signals in the Tetrachromatic Zebrafish Visual System. International Journal of Molecular Sciences. 27:

Deng, J., Li, Y., Hu, M., Hu, C., Lin, J., Li, Q., Xu, X., Liu, C. (2026) Role and Impact of the brsk2 Gene in Zebrafish Retinal Development and Visual Function Characterized by Behavioral, Histological, and Transcriptomic Analyses. International Journal of Molecular Sciences. 27:

Owusu Poku, E., Fonte, M.R., Jensen, T.J., Inman, S.P., Mackin, R.D., Stenkamp, D.L. (2025) Thyroid hormone receptor beta-2 (TRβ2) overexpression modulates photoreceptor phenotype diversity in a ligand-dependent manner. Frontiers in cell and developmental biology. 13:16979301697930

Pidishetty, D., Damera, S.K., Murugavel, M., Susaimanickam, P.J., Chittajallu, S.N.S.H., Kushawah, G., Sarkar, P., Bharadwaj, S.R., Mishra, R., Mariappan, I. (2025) Loss of retinal stem cell reserve and lipofuscin accumulation accelerates cone-rod degeneration and replicates Stargardt disease in abca4b null zebrafish. Scientific Reports. :

Tevar, A., Aroca-Aguilar, J.D., Atiénzar-Aroca, R., Ramírez, A.I., Fernández-Albarral, J.A., Escribano, J. (2025) Zebrafish adamtsl4 knockout recapitulates key features of human ADAMTSL4-related diseases: a gene involved in extracellular matrix organization, cell junctions and development. Experimental Eye Research. :110572110572

Varela, T., Varela, D., Conceição, N., Cancela, M.L. (2025) Transcriptomic Profiling of Zebrafish Mutant for cdkl5 Reveals Dysregulated Gene Expression Associated with Neuronal, Muscle, Visual and Skeletal Development. International Journal of Molecular Sciences. 26:

Cao, M., Xu, T., Song, Y., Wei, S., Wang, H., Guo, X., Yin, D. (2024) Brominated Flame Retardant HBCD and Artificial Light at Night Synergically Caused Visual Disorder and Sleep Difficulty in Zebrafish Larvae. Environmental science & technology. 58(39):17247-17258

Fagundes, T., Pannetier, P., Gölz, L., Behnstedt, L., Morthorst, J., Vergauwen, L., Knapen, D., Holbech, H., Braunbeck, T., Baumann, L. (2024) The generation gap in endocrine disruption: Can the integrated fish endocrine disruptor test (iFEDT) bridge the gap by assessing intergenerational effects of thyroid hormone system disruption?. Aquatic toxicology (Amsterdam, Netherlands). 272:106969106969

Hu, H., Qin, Y., Qu, Z., Huang, Y., Ren, X., Liu, M., Liu, F., Gao, P. (2024) The Zpr-3 Antibody Recognizes the 320-354 Region of Rho and Labels Both Rods and Green Cones in Zebrafish. Zebrafish. 21(6):394-400

Lazcano, I., Pech-Pool, S.M., Maldonado-Lira, M.F., Olvera, A., Darras, V.M., Orozco, A. (2024) Ontogeny of Thyroid Hormone Signaling in the Retina of Zebrafish: Effects of Thyroidal Status on Retinal Morphology, Cell Survival, and Color Preference. International Journal of Molecular Sciences. 25(22):

Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121

Yang, H.Z., Zhuo, D., Huang, Z., Luo, G., Liang, S., Fan, Y., Zhao, Y., Lv, X., Qiu, C., Zhang, L., Liu, Y., Sun, T., Chen, X., Li, S.S., Jin, X. (2024) Deficiency of Acetyltransferase nat10 in Zebrafish Causes Developmental Defects in the Visual Function. Investigative ophthalmology & visual science. 65:3131

Zheng, N., Liao, T., Zhang, C., Zhang, Z., Yan, S., Xi, X., Ruan, F., Yang, C., Zhao, Q., Deng, W., Huang, J., Huang, Z.T., Chen, Z.F., Wang, X., Qu, Q., Zuo, Z., He, C. (2024) Quantum Dots-caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(46):e2406343

Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:

Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273

Farre, A.A., Thomas, P., Huang, J., Poulsen, R.A., Owusu Poku, E., Stenkamp, D.L. (2023) Plasticity of cone photoreceptors in adult zebrafish revealed by thyroid hormone exposure. Scientific Reports. 13:1569715697

Lu, K., Liang, X.F., Tang, S.L., Wu, J., Zhang, L., Wang, Y., Chai, F. (2023) Role of short-wave-sensitive 1 (sws1) in cone development and first feeding in larval zebrafish. Fish physiology and biochemistry. 49(5):801-813

Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107

Wang, Y.Y., Liang, X.F., Lu, K. (2023) Knockout of SWS2 in zebrafish (Danio rerio) reveals its roles in feeding and phototactic behaviors. Gene. 897:148059

Zhang, J., Jing, M., Li, P., Sun, L., Pi, X., Jiang, N., Zhu, K.K., Li, H., Li, J., Wang, M., Zhang, J., Liu, M., Mu, H., Hu, Y., Cui, X. (2023) Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1869(4):166645

Liu, F., Qin, Y., Huang, Y., Gao, P., Li, J., Yu, S., Jia, D., Chen, X., Lv, Y., Tu, J., Sun, K., Han, Y., Reilly, J., Shu, X., Lu, Q., Tang, Z., Xu, C., Luo, D., Liu, M. (2022) Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLoS Genetics. 18:e1009841

Liang, Q., Afriyie, G., Chen, Z., Xu, Z., Dong, Z., Wang, Z., Guo, Y. (2021) Analysis of Opsin Gene Family of Crimson Snapper (Lutjanus erythropterus). Gene. 807:145960

Lourenço, R., Brandão, A.S., Borbinha, J., Gorgulho, R., Jacinto, A. (2021) Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas. Frontiers in cell and developmental biology. 9:667796

Coomer, C.E., Wilson, S.G., Titialii-Torres, K.F., Bills, J.D., Krueger, L.A., Petersen, R.A., Turnbaugh, E.M., Janesch, E.L., Morris, A.C. (2020) Her9/Hes4 is required for retinal photoreceptor development, maintenance, and survival. Scientific Reports. 10:11316

Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108

Nadolski, N.J., Balay, S.D., Wong, C.X.L., Waskiewicz, A.J., Hocking, J.C. (2020) Abnormal Cone and Rod Photoreceptor Morphogenesis in gdf6a Mutant Zebrafish. Investigative ophthalmology & visual science. 61:9

Qian, L., Qi, S., Wang, Z., Magnuson, J.T., Volz, D.C., Schlenk, D., Jiang, J., Wang, C. (2020) Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems. Journal of hazardous materials. 404:124083

Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538

Sundaramurthi, H., Roche, S.L., Grice, G.L., Moran, A., Dillion, E.T., Campiani, G., Nathan, J.A., Kennedy, B.N. (2020) Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness. Frontiers in cell and developmental biology. 8:689

Volkov, L.I., Kim-Han, J.S., Saunders, L.M., Poria, D., Hughes, A.E.O., Kefalov, V.J., Parichy, D.M., Corbo, J.C. (2020) Thyroid hormone receptors mediate two distinct mechanisms of long-wavelength vision. Proceedings of the National Academy of Sciences of the United States of America. 117(26):15262-15269

Wang, H., Yang, Z., Li, X., Huang, D., Yu, S., He, J., Li, Y., Yan, J. (2020) Single-cell in vivo imaging of cellular circadian oscillators in zebrafish. PLoS Biology. 18:e3000435

Zhang, R., Silic, M.R., Schaber, A., Wasel, O., Freeman, J.L., Sepúlveda, M.S. (2020) Exposure route affects the distribution and toxicity of polystyrene nanoplastics in zebrafish. The Science of the total environment. 724:138065

Zhao, G., Sun, H., Zhang, T., Liu, J.X. (2020) Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis. Cell communication and signaling : CCS. 18:45

Mackin, R.D., Frey, R.A., Gutierrez, C., Farre, A.A., Kawamura, S., Mitchell, D.M., Stenkamp, D.L. (2019) Endocrine regulation of multichromatic color vision. Proceedings of the National Academy of Sciences of the United States of America. 116(34):16882-16891

Mitchell, D.M., Sun, C., Hunter, S.S., New, D.D., Stenkamp, D.L. (2019) Regeneration associated transcriptional signature of retinal microglia and macrophages. Scientific Reports. 9:4768

Ogawa, Y., Shiraki, T., Asano, Y., Muto, A., Kawakami, K., Suzuki, Y., Kojima, D., Fukada, Y. (2019) Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 116(10):4651-4660

Shi, Q., Wang, Z., Chen, L., Fu, J., Han, J., Hu, B., Zhou, B. (2019) Optical toxicity of triphenyl phosphate in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 210:139-147

Cai, S., Chen, Y., Shang, Y., Cui, J., Li, Z., Li, Y. (2018) Knockout of zebrafish interleukin 7 receptor (IL7R) by the CRISPR/Cas9 system delays retinal neurodevelopment. Cell Death & Disease. 9:273

Crespo, C., Knust, E. (2018) Characterisation of maturation of photoreceptor cell subtypes during zebrafish retinal development. Biology Open. 7(11):

Crespo, C., Soroldoni, D., Knust, E. (2018) A novel transgenic zebrafish line for red opsin expression in outer segments of photoreceptor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(7):951-959

Miyazaki, T., Kondrashev, S.L., Tsuchiya, T. (2018) Visual pigment genes and absorbance spectra in the Japanese sardine Sardinops melanostictus (Teleostei: Clupeiformes). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 218:54-63

Sun, C., Mitchell, D.M., Stenkamp, D.L. (2018) Isolation of photoreceptors from mature, developing, and regenerated zebrafish retinas, and of microglia/macrophages from regenerating zebrafish retinas. Experimental Eye Research. 177:130-144

Zhang, Y., Wang, Z., Zhao, G., Liu, J.X. (2018) Silver nanoparticles affect lens rather than retina development in zebrafish embryos. Ecotoxicology and environmental safety. 163:279-288

Lewis, T.R., Kundinger, S.R., Pavlovich, A.L., Bostrom, J.R., Link, B.A., Besharse, J.C. (2017) Cos2/Kif7 and OSM-3/Kif17 Regulate Onset of Outer Segment Development in Zebrafish Photoreceptors Through Distinct Mechanisms. Developmental Biology. 425(2):176-190

Zhang, L., Zhang, X., Zhang, G., Pang, C.P., Leung, Y.F., Zhang, M., Zhong, W. (2017) Expression profiling of the retina of pde6c, a zebrafish model of retinal degeneration. Scientific data. 4:170182

Glaviano, A., Smith, A.J., Blanco, A., McLoughlin, S., Cederlund, M.L., Heffernan, T., Sapetto-Rebow, B., Alvarez, Y., Yin, J., Kennedy, B.N. (2016) A method for isolation of cone photoreceptors from adult zebrafish retinae. BMC Neuroscience. 17:71

Houbrechts, A.M., Vergauwen, L., Bagci, E., Van Houcke, J., Heijlen, M., Kulemeka, B., Hyde, D.R., Knapen, D., Darras, V.M. (2016) Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function. Molecular and Cellular Endocrinology. 424:81-93

Davies, W.I., Tamai, T.K., Zheng, L., Fu, J.K., Rihel, J., Foster, R.G., Whitmore, D., Hankins, M.W. (2015) An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function. Genome research. 25(11):1666-79

Li, W.H., Zhou, L., Li, Z., Wang, Y., Shi, J.T., Yang, Y.J., Gui, J.F. (2015) Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation. International journal of biological sciences. 11(6):688-700

Mitchell, D.M., Stevens, C.B., Frey, R.A., Hunter, S.S., Ashino, R., Kawamura, S., Stenkamp, D.L. (2015) Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish. PLoS Genetics. 11:e1005483

Ogawa, Y., Shiraki, T., Kojima, D., Fukada, Y. (2015) Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish. Proceedings. Biological sciences. 282(1812):20150659

Lagman, D., Ocampo Daza, D., Widmark, J., Abalo, X.M., Sundström, G., and Larhammar, D. (2013) The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications. BMC Evolutionary Biology. 13:238

Priyadarshini, M., Tuimala, J., Chen, Y.C., and Panula, P. (2013) A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling. Neurobiology of disease. 54:127-38

Veneman, W.J., Stockhammer, O.W., de Boer, L., Zaat, S.A., Meijer, A.H., and Spaink, H.P. (2013) A zebrafish high throughput screening system used for Staphylococcus epidermidis infection marker discovery. BMC Genomics. 14(1):255

Weber, A., Hochmann, S., Cimalla, P., Gärtner, M., Kuscha, V., Hans, S., Geffarth, M., Kaslin, J., Koch, E., and Brand, M. (2013) Characterization of light lesion paradigms and optical coherence tomography as tools to study adult retina regeneration in zebrafish. PLoS One. 8(11):e80483

Davies, W.I., Zheng, L., Hughes, S., Tamai, T.K., Turton, M., Halford, S., Foster, R.G., Whitmore, D., and Hankins, M.W. (2011) Functional diversity of melanopsins and their global expression in the teleost retina. Cellular and molecular life sciences : CMLS. 68(24):4115-32

Linder, B., Dill, H., Hirmer, A., Brocher, J., Lee, G.P., Mathavan, S., Bolz, H.J., Winkler, C., Laggerbauer, B., and Fischer, U. (2011) Systemic splicing factor deficiency causes tissue-specific defects: A zebrafish model for Retinitis pigmentosa. Human molecular genetics. 20(2):368-377

Morrow, J.M., Lazic, S., and Chang, B.S. (2011) A novel rhodopsin-like gene expressed in zebrafish retina. Visual neuroscience. 28(4):325-35

Allison, W.T., Barthel, L.K., Skebo, K.M., Takechi, M., Kawamura, S., and Raymond, P.A. (2010) Ontogeny of cone photoreceptor mosaics in zebrafish. The Journal of comparative neurology. 518(20):4182-4195

Tsujimura, T., Hosoya, T., and Kawamura, S. (2010) A single enhancer regulating the differential expression of duplicated red-sensitive opsin genes in zebrafish. PLoS Genetics. 6(12):e1001245

Alvarez-Delfin, K., Morris, A.C., Snelson, C.D., Gamse, J.T., Gupta, T., Marlow, F.L., Mullins, M.C., Burgess, H.A., Granato, M., and Fadool, J.M. (2009) Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proceedings of the National Academy of Sciences of the United States of America. 106(6):2023-2028

Huang, H.Y., Dai, E.S., Liu, J.T., Tu, C.T., Yang, T.C., and Tsai, H.J. (2009) The embryonic expression patterns and the knockdown phenotypes of zebrafish ADP-ribosylation factor-like 6 interacting protein gene. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(1):232-240

Takechi, M., and Kawamura, S. (2005) Temporal and spatial changes in the expression pattern of multiple red and green subtype opsin genes during zebrafish development. The Journal of experimental biology. 208(Pt.7):1337-1345

Vihtelic, T.S., Fadool, J.M., Gao, J., Thornton, K.A., Hyde, D.R., and Wistow, G. (2005) Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Molecular Vision. 11:1083-1100

Kennedy, M.J., Dunn, F.A., and Hurley, J.B. (2004) Visual pigment phosphorylation but not transducin translocation can contribute to light adaptation in zebrafish cones. Neuron. 41(6):915-928

Chinen, A., Hamaoka, T., Yamada, Y., and Kawamura, S. (2003) Gene duplication and spectral diversification of cone visual pigments of zebrafish. Genetics. 163(2):663-675

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (22):

Zebrafish Nomenclature Committee (2026) Nomenclature Data Curation (2026). Nomenclature Committee Submission.

Zebrafish Nomenclature Committee (2023) Nomenclature Data Curation (2023). Nomenclature Committee Submission.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

Zebrafish Nomenclature Committee (2018) Nomenclature Data Curation (2018). Nomenclature Committee Submission.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

GOA, HGNC, AgBase and UniProtKB curators (2007) Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. ZFIN Direct Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.