Publication	Data		Fish	Anatomy
Tan et al., 2022	Fig. 12		pax2atu29a/tu29a	otic placode atoh1a expression decreased amount, abnormal otic placode atoh1a expression decreased distribution, abnormal
Lusk et al., 2021	Fig. 2		pax2atu29a/tu29a	optic furrow closure incomplete, abnormal
	Fig. 3		pax2atu29a/tu29a	optic furrow ab1-lama1 labeling increased amount, abnormal optic furrow ab1-lama1 labeling increased distribution, abnormal
	Fig. 4		pax2atu29a/tu29a; ba4Tg	optic furrow GFP expression increased amount, abnormal optic furrow GFP expression increased distribution, abnormal
	Fig. 5		pax2atu29a/tu29a; s896Tg; z200Tg	optic fissure endothelial cell EGFP expression decreased amount, abnormal optic fissure endothelial cell EGFP expression decreased distribution, abnormal optic furrow endothelial cell EGFP expression decreased amount, abnormal optic furrow endothelial cell EGFP expression decreased distribution, abnormal optic furrow endothelial cell EGFP expression increased amount, abnormal optic furrow endothelial cell EGFP expression increased distribution, abnormal
	Fig. 6		pax2atu29a/tu29a	midbrain hindbrain boundary ab1-casp3 labeling increased distribution, abnormal periocular mesenchyme ab1-casp3 labeling increased distribution, abnormal
Pachoensuk et al., 2020	Fig. 1		pax2aszu2/+ ,   pax2aszu2/szu2	caudal fin morphology, abnormal heart edematous, abnormal whole organism elliptic, abnormal yolk morphology, abnormal
	Fig. 2		pax2aszu2/szu2	fertilization decreased occurrence, abnormal oocyte decreased amount, abnormal whole organism decreased size, abnormal
	Fig. 3		pax2aszu2/szu2	unfertilized egg pax2a expression decreased amount, abnormal whole organism pax2a expression decreased amount, abnormal
Weaver et al., 2020	Figure 1		pax2atu29a/tu29a	optic furrow basement membrane increased amount, abnormal optic furrow filamentous actin decreased amount, abnormal optic furrow laminin complex increased amount, abnormal
	Figure 2		pax2atu29a/tu29a; is5Tg ,   pax2atu29a/tu29a	head cldn5b expression decreased amount, abnormal head flt4 expression decreased amount, abnormal head tjp1a expression decreased amount, abnormal head tln1 expression decreased amount, abnormal hyaloid vessel vascular associated smooth muscle cell decreased amount, abnormal lens hyaloid vessel decreased size, abnormal lens hyaloid vessel incomplete structure, abnormal midbrain hindbrain boundary tln1 expression decreased amount, abnormal optic fissure tln1 expression decreased amount, abnormal optic furrow vascular associated smooth muscle cell decreased amount, abnormal retina vascular associated smooth muscle cell decreased amount, abnormal
	Figure 3		pax2atu29a/tu29a	eye anatomical region vegfaa expression decreased amount, abnormal eye anatomical region vegfab expression decreased amount, abnormal eye anatomical region vegfc expression decreased amount, abnormal head vegfaa expression decreased amount, abnormal head vegfab expression decreased amount, abnormal head vegfc expression decreased amount, abnormal
	Figure 5		pax2atu29a/tu29a	optic furrow mmp14a expression decreased amount, abnormal optic furrow mmp14b expression decreased amount, abnormal optic furrow mmp2 expression decreased amount, abnormal
Charlton-Perkins et al., 2019	Figure 4		mi2001Tg + CRISPR5-pax2a + CRISPR6-pax2a	inner limiting membrane broken, abnormal Muller cell cell body position, abnormal Muller cell cell body spatial pattern, abnormal Muller cell physical object quality, abnormal outer limiting membrane broken, abnormal retina disorganized, abnormal retinal inner plexiform layer morphology, abnormal retinal outer plexiform layer morphology, abnormal
	Figure S4		pax2acu17/cu17; mi2001Tg ,   mi2001Tg + CRISPR5-pax2a + CRISPR6-pax2a	Muller cell pax2a expression absent, abnormal Muller cell pax2a expression decreased amount, abnormal
	Table S4		mi2001Tg + CRISPR5-pax2a + CRISPR6-pax2a	inner limiting membrane broken, abnormal Muller cell cell body displaced, abnormal Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal Muller cell morphology, abnormal Muller cell physical object quality, abnormal outer limiting membrane broken, abnormal retinal inner plexiform layer decreased thickness, abnormal retinal inner plexiform layer morphology, abnormal
Cao et al., 2018	Fig. 6		AB + MO4-pax2a	optic furrow closure incomplete, abnormal optic furrow morphology, abnormal optic furrow open, abnormal
Gou et al., 2018	Fig. 6		pax2atu29a/tu29a (AB)	otic placode pax2a expression decreased amount, abnormal otic placode pax2a expression decreased distribution, abnormal otic vesicle pax2a expression decreased amount, abnormal otic vesicle pax2a expression decreased distribution, abnormal
Gou et al., 2018	Fig. 8		x21Tg/x21Tg + MO1-pax2a + MO4-tp53 (AB)	otic vesicle atoh1a expression increased amount, abnormal otic vesicle atoh1a expression increased distribution, abnormal otic vesicle neurog1 expression increased amount, abnormal otic vesicle neurog1 expression increased distribution, abnormal
Trubiroha et al., 2018	Fig. 3		ulb4Tg + CRISPR5-pax2a	thyroid follicle aplastic/hypoplastic, abnormal
Kantarci et al., 2016	Fig. 4		pax2atu29a/tu29a	otic vesicle neuroblast delamination increased occurrence, abnormal otic vesicle neuroblast proliferation decreased occurrence, abnormal otic vesicle ventro-lateral region gsc expression increased distribution, abnormal
Ota et al., 2016	Fig. 2		pax2auy221Tg/uy221Tg	midbrain EGFP expression increased distribution, abnormal midbrain EGFP expression spatial pattern, abnormal midbrain hindbrain boundary pax2a expression absent, abnormal midbrain hindbrain boundary absent, abnormal
	Fig. 3		pax2auy221Tg/uy221Tg	cranial nerve II neuron projection physical object quality, abnormal midbrain EGFP expression increased distribution, abnormal midbrain EGFP expression spatial pattern, abnormal midbrain hindbrain boundary absent, abnormal midbrain hindbrain boundary EGFP expression absent, abnormal optic chiasm cranial nerve II malformed, abnormal optic chiasm EGFP expression absent, abnormal thyroid follicle EGFP expression decreased distribution, abnormal thyroid follicle morphology, abnormal
Shim et al., 2016	Fig. 5		WT + MO1-pax2a ,   s843Tg + MO1-pax2a	cilium assembly disrupted, abnormal determination of heart left/right asymmetry disrupted, abnormal heart edematous, abnormal peripheral olfactory organ cilium morphology, abnormal
	Fig. S1		WT + MO1-pax2a ,   WT + MO6-pax2a	brain hydrocephalic, abnormal heart edematous, abnormal otolith malformed, abnormal post-vent region curved, abnormal
Bedell et al., 2012	Fig. 5		pax2atb21/tb21 ,   pax2atb21/tb21; li1Tg	pronephric glomerulus aplastic, abnormal pronephric tubule anterior region malformed, abnormal pronephric tubule dilated, abnormal
Porreca et al., 2012	Fig. 4		pax2atu29a/tu29a	brain lacks all parts of type midbrain hindbrain boundary, abnormal
Gregory-Evans et al., 2011	Fig. 4		pax2atu29a/tu29a	closure of optic fissure decreased process quality, abnormal eye apoptotic process increased occurrence, abnormal optic fissure increased width, abnormal whole organism apoptotic process increased occurrence, abnormal
Bae et al., 2009	text only		pax2ark9/rk9	midbrain hindbrain boundary malformed, abnormal
Shima et al., 2009	Fig. 5		pax2atu29a/tu29a	heart edematous, abnormal optic chiasm cranial nerve II ipsilateral to optic chiasm cranial nerve II, abnormal otic vesicle decreased size, abnormal
Moosajee et al., 2008	Fig. 7		pax2atu29a/tu29a	eye decreased size, abnormal lens decreased size, abnormal lens opaque, abnormal pericardium edematous, abnormal retina layer formation disrupted, abnormal swim bladder aplastic, abnormal whole organism decreased length, abnormal
Erickson et al., 2007	Fig. 1		pax2ab593/b593	cerebellum malformed, abnormal midbrain aplastic, abnormal midbrain hindbrain boundary aplastic, abnormal optic tectum malformed, abnormal
Molina et al., 2007	Fig. 4		pax2atu29a/tu29a; pt6Tg	midbrain hindbrain boundary morphology, abnormal
Nechiporuk et al., 2007	Fig. S1		pax2atu29a/tu29a	cranial ganglion neuron decreased amount, abnormal parasympathetic nervous system development disrupted, abnormal
Kwak et al., 2006	Fig. 7		pax2atu29a/tu29a	apoptotic process increased occurrence, abnormal utricle lacks parts or has fewer parts of type hair cell, abnormal
Phenotype Annotation (1994-2006)	Fig. for (b593)		pax2ab593	midbrain hindbrain boundary quality, abnormal
	Fig. for (tb21)		pax2atb21/tb21	anatomical system quality, abnormal brain quality, abnormal midbrain hindbrain boundary quality, abnormal nervous system quality, abnormal pronephros quality, abnormal retinal ganglion cell axon guidance quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (th44)		pax2ath44/th44	anatomical system quality, abnormal brain quality, abnormal midbrain hindbrain boundary quality, abnormal nervous system quality, abnormal pronephros quality, abnormal retinal ganglion cell axon guidance quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (tm243a)		pax2atm243a/tm243a	anatomical system quality, abnormal brain quality, abnormal midbrain hindbrain boundary quality, abnormal nervous system quality, abnormal pronephros quality, abnormal retinal ganglion cell axon guidance quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (tu29a)		pax2atu29a/tu29a	anatomical system quality, abnormal brain quality, abnormal midbrain hindbrain boundary quality, abnormal nervous system quality, abnormal pronephros quality, abnormal retinal ganglion cell axon guidance quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (ty22b)		pax2aty22b/ty22b	anatomical system quality, abnormal brain quality, abnormal midbrain hindbrain boundary quality, abnormal nervous system quality, abnormal pronephros quality, abnormal retinal ganglion cell axon guidance quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (ty31z)		pax2aty31a/ty31a	anatomical system quality, abnormal brain quality, abnormal midbrain hindbrain boundary quality, abnormal nervous system quality, abnormal pronephros quality, abnormal retinal ganglion cell axon guidance quality, abnormal whole organism lethal (sensu genetics), abnormal
O'Hara et al., 2005	Fig. 7		pax2aunspecified	midbrain apoptotic, abnormal
Scholpp et al., 2003	Fig. 1		pax2atu29a/tu29a	commissura cerebelli aplastic, abnormal cranial nerve IV aplastic, abnormal midbrain hindbrain boundary aplastic, abnormal optic tectum aplastic, abnormal
	Fig. 2		pax2atu29a/tu29a	caudal commissure increased size, abnormal epiphysis decreased width, abnormal
	text only		pax2atu29a/tu29a	diencephalon distended, abnormal hindbrain distended, abnormal
Wendl et al., 2002	Fig. 4		pax2atu29a/tu29a	thyroid follicle aplastic, abnormal
Kudoh et al., 2001	Fig. 3		pax2aunspecified/unspecified	optic tectum decreased size, abnormal
Majumdar et al., 2000	Fig. 1		pax2atb21/tb21 ,   pax2atu29a/tu29a	pronephros development process quality, abnormal
	Fig. 6		pax2atu29a/tu29a	pronephric duct central region distended, abnormal pronephric duct epithelial cell flattened, abnormal pronephric duct lacks all parts of type epithelial cell brush border, abnormal
Guo et al., 1999	Fig. 6		pax2atu29a/tu29a	locus ceruleus development disrupted, abnormal locus coeruleus absent, abnormal
Riley et al., 1999	Fig. 4		pax2atb21/tb21	macula has extra parts of type hair cell, abnormal
	Fig. 5		pax2atb21/tb21	macula utricle has extra parts of type hair cell, abnormal
	text only		pax2atb21/tb21	otic vesicle has extra parts of type hair cell, abnormal
Lun et al., 1998	Fig. 1		pax2atb21/tb21 ,   pax2atu29a/tu29a	cerebellum absent, abnormal gut epithelium edematous, abnormal midbrain hindbrain boundary absent, abnormal midbrain-hindbrain boundary development arrested, abnormal midbrain-hindbrain boundary development disrupted, abnormal optic tectum absent, abnormal optic tectum decreased size, abnormal pericardium edematous, abnormal
Pfeffer et al., 1998	Fig. 7		pax2atu29a/tu29a	brain lacks all parts of type midbrain hindbrain boundary, abnormal midbrain-hindbrain boundary initiation process quality, abnormal
	Fig. 8		pax2atu29a/tu29a	midbrain hindbrain boundary neural keel physical object quality, abnormal otic vesicle physical object quality, abnormal
	Fig. 9		pax2atu29a/tu29a	midbrain hindbrain boundary physical object quality, abnormal optic cup physical object quality, abnormal pronephric duct physical object quality, abnormal pronephros physical object quality, abnormal
Reifers et al., 1998	Fig. 9		pax2atu29a/tu29a	midbrain hindbrain boundary physical object quality, abnormal midbrain-hindbrain boundary development decreased process quality, abnormal
Macdonald et al., 1997	Fig. 3		pax2aty31a/ty31a ,   pax2atu29a/tu29a	optic fissure closure incomplete, abnormal retinal neural layer closure incomplete, abnormal retinal pigmented epithelium closure incomplete, abnormal
	Fig. 4		pax2atu29a/tu29a	cranial nerve II malformed, abnormal optic nerve development disrupted, abnormal
Brand et al., 1996	Fig. 1		pax2aty31a/ty31a ,   pax2ath44/th44	blood circulation disrupted, abnormal cerebellum absent, abnormal midbrain hindbrain boundary absent, abnormal optic tectum absent, abnormal optic tectum decreased size, abnormal otic vesicle morphology, abnormal pronephric duct absent, abnormal
	Fig. 2		pax2aty22b/ty22b ,   pax2atu29a/tu29a	optic tectum apoptotic, abnormal optic tectum cell degenerate, abnormal optic tectum cell refractile, abnormal
	Fig. 3		pax2ath44/th44 ,   pax2aty22b/ty22b	ansulate commissure decreased size, abnormal cranial nerve IV aplastic, abnormal forebrain midbrain boundary decreased distance hindbrain commissure, abnormal oculomotor nucleus has fewer parts of type neuron, abnormal trochlear motor nucleus has fewer parts of type neuron, abnormal
	Fig. 4		pax2ath44/th44	midbrain hindbrain boundary aplastic, abnormal
	text only		pax2aty31a/ty31a ,   pax2atb21/tb21 ,   pax2aty22b/ty22b ,   pax2atm243a/tm243a ,   pax2atu29a/tu29a	blood circulation disrupted, abnormal cerebellum absent, abnormal midbrain hindbrain boundary absent, abnormal optic tectum absent, abnormal optic tectum decreased size, abnormal otic vesicle decreased size, abnormal pronephric duct absent, abnormal
Chen et al., 1996	Table 2		pax2aty31a/ty31a ,   pax2atb21/tb21 ,   pax2aty22b/ty22b ,   pax2ath44/th44 ,   pax2atm243a/tm243a ,   pax2atu29a/tu29a	midbrain hindbrain boundary absent, abnormal pronephros absent, abnormal
Furutani-Seiki et al., 1996	Fig. 6		pax2ath44/th44	midbrain hindbrain boundary apoptotic, abnormal
Trowe et al., 1996	Fig. 8		pax2aty31a/ty31a ,   pax2atb21/tb21	optic tectum decreased size, abnormal optic tectum morphology, abnormal retinal ganglion cell axon guidance process quality, abnormal whole organism viability, abnormal
	Table 1		pax2ath44/th44 ,   pax2aty22b/ty22b ,   pax2atm243a/tm243a ,   pax2atu29a/tu29a	optic tectum decreased size, abnormal optic tectum morphology, abnormal retinal ganglion cell axon guidance process quality, abnormal whole organism viability, abnormal