FIGURE

Fig. 1

ID

ZDB-FIG-070313-5

Publication

Lun et al., 1998 - A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary

Other Figures

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Fig. 1

Lateral views of wild-type and noi mutant embryos. (A) Wildtype embryo at 24 hours pf. (B) Schematic drawing of the structures seen in A. (C) Strong noi^tu29a mutant, which lacks MHB, tectum (asterisk) and cerebellum. (D) Weak noi^tb21 phenotype; a partially formed tectum is observed, the caudal end marked by the arrowhead. (E) A wild-type embryo at day 7. A homozygous mutant for noi^tu29a of the same age is seen in (F), showing severe oedema of the pericard and gut epithelium, causing delayed development. (G) Survival rates of different noi alleles. n=30 mutant embryos per allele were analyzed. The difference between the strong noi^tu29a allele and the weaker alleles is clearly visible. The mutants never feed and die within 2 weeks. c, cerebellum, di, diencephalon, epi, epiphysis, pros, prosencephalon, rh, rhombencephalon, tc, tectum, tg, tegmentum, v, ventricle.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pax2a^tb21/tb21 pax2a^tu29a/tu29a
Observed In:	cerebellum gut epithelium midbrain hindbrain boundary midbrain-hindbrain boundary development optic tectum pericardium
Stage Range:	Prim-5 to Days 7-13

Phenotype Detail

Acknowledgments

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