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Ma et al., 2025 - Functional characterization of MFSD3 in auditory system and zebrafish embryogenesis

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FIGURE 4

Zebrafish with Mfsd3 deficiency exhibited upregulated Wnt/β-catenin signaling activity. (A) Schematic diagram depicting the potential regulatory action of mfsd3 on the Wnt/β-catenin signaling pathway. (B) Wnt/β-catenin signaling pathway was upregulated in mfsd3 morphants. Endogenous dkk1b, wnt8a, wnt9a, lrp5, lrp6, frzb, fzd7a, fzd7b, gsk-3β, axin1, axin2, mycn, lef1, myca, β-catenin and COX2 in control and mfsd3 morphants measured by qRT-PCR assay (n = 6–10 individual embryos). The dkk1b, wnt8a, lrp6, frzb and COX2 were all upregulated significantly in the mfsd3 morphants group. ***P < 0.001; **P < 0.01; *P < 0.05.

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