Gene
axin1
- ID
- ZDB-GENE-000403-1
- Name
- axin 1
- Symbol
- axin1 Nomenclature History
- Previous Names
-
- masterblind
- mbl
- wu:fi22e03
- wu:fj14c08
- wu:fk11b03 (1)
- zgc:109872
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have protein homodimerization activity. Involved in several processes, including embryonic morphogenesis; negative regulation of Wnt signaling pathway; and regionalization. Localizes to beta-catenin destruction complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is expressed in forebrain; habenula; and midbrain. Orthologous to human AXIN1 (axin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 30 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, somatic | 114550 |
| Craniometadiaphyseal osteosclerosis with hip dysplasia | 620558 | ||
| ?Caudal duplication anomaly | 607864 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001158 | DIX domain |
| Domain | IPR014936 | Axin beta-catenin binding |
| Domain | IPR016137 | RGS domain |
| Domain | IPR032101 | Axin-1/2, tankyrase-binding domain |
| Family | IPR043581 | Axin-like |
| Homologous_superfamily | IPR024066 | RGS, subdomain 1/3 |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036305 | RGS domain superfamily |
| Homologous_superfamily | IPR038207 | DIX domain superfamily |
| Homologous_superfamily | IPR044926 | RGS, subdomain 2 |
Domain Details Per Protein
| Protein | Length | Axin-1/2, tankyrase-binding domain | Axin beta-catenin binding | Axin-like | DIX domain | DIX domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 1/3 | RGS, subdomain 2 | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AY92
|
871 | ||||||||||
|
UniProtKB:P57094
|
835 |
Interactions and Pathways
No data available
Plasmids
No data available