ZFIN ID: ZDB-GENE-990708-5
Gene Name: dickkopf WNT signaling pathway inhibitor 1b
Gene Symbol: dkk1b    Nomenclature History

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Previous Name: dkk1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have co-receptor binding activity and receptor antagonist activity. Involved in several processes, including animal organ development; hepatic duct development; and sensory epithelium regeneration. Localizes to cytoplasm and extracellular region. Is expressed in several structures, including ectoderm; embryonic structure; median fin fold; pharyngeal arch; and sensory system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1).
Genome Resources: Alliance (1),  Gene:30197 (1),  Ensembl(GRCz11):ENSDARG00000045219 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9337 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16096 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19025 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27882 Point Mutation Unknown Splice Site ENU
    sa27883 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dkk1b N/A 2
    MO2-dkk1b N/A 5
    MO3-dkk1b N/A 4
    MO4-dkk1b N/A 1
    MO5-dkk1b N/A 2
    DISEASE ASSOCIATED WITH dkk1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dkk1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell dedifferentiation (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dkk1b-201 (1)    Ensembl 894
    dkk1b-202 (1)    Ensembl 1133
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dkk1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:dkk1b-FLAG) hsp70l dkk1bFLAG Danio rerio 1 2
    Tg(hsp70l:dkk1b-GFP) hsp70l dkk1bGFP Danio rerio 1 98
    Tg(hsp70l:dkk1b-mCherry) hsp70l dkk1bmCherry Danio rerio 1 2
    Tg(TETRE:dkk1b-GFP) dkk1bGFP Danio rerio 1 3
    Tg(UAS:dkk1b-UTRnanos3) UAS dkk1bnanos3UTR Danio rerio 1 1
    Tg2(hsp70l:dkk1b-GFP) hsp70l dkk1bGFP Danio rerio 1 3
    TgBAC(dkk1b:EGFP) dkk1b EGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    dkk1b Contained in: [BAC] DKEY-31K12 (1) (order this)
    dkk1b Encodes: [cDNA] MGC:152787 (1), MGC:192261 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131003 (1) 841 nt
    Genomic GenBank:BX649533 (1) 128710 nt
    Select Tool
    Polypeptide UniProtKB:A0A0B5JK99 (1) 241 aa
    Sequence Information (all 27)
    ORTHOLOGY for dkk1b ( Chr: 12 )
    CITATIONS (206)