ZFIN ID: ZDB-GENE-980526-362
Gene Name: catenin (cadherin-associated protein), beta 1
Gene Symbol: ctnnb1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: ctnnb (1), id:ibd2058, wu:fb73e10 (1), wu:fi81c06 (1), wu:fk25h01

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Exhibits cadherin binding activity. Involved in several processes, including determination of dorsal/ventral asymmetry; glomerular filtration; and positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification. Localizes to several cellular components, including the catenin complex; intercalated disc; and zonula adherens. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Is expressed in several structures, including EVL; adaxial cell; brain; germ ring; and gonad. Orthologous to human CTNNB1 (catenin beta 1).
Genome Resources: Alliance (1),  Gene:30265 (1),  Ensembl(GRCz11):ENSDARG00000014571 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hg101 Small Deletion Unknown Unknown CRISPR
la019872Tg Transgenic Insertion Unknown Unknown DNA
sa11589 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ctnnb1 4
    CRISPR2-ctnnb1
    2
    MO1-ctnnb1 N/A 10
    MO2-ctnnb1 N/A 7
    MO3-ctnnb1 N/A 3
    MO4-ctnnb1 N/A 1
    DISEASE ASSOCIATED WITH ctnnb1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant non-syndromic intellectual disability 19 Alliance Neurodevelopmental disorder with spastic diplegia and visual defects 615075
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    exudative vitreoretinopathy 7 Alliance Exudative vitreoretinopathy 7 617572
    hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
    medulloblastoma Alliance Medulloblastoma, somatic 155255
    ovarian cancer Alliance Ovarian cancer, somatic 167000
    pilomatrixoma Alliance Pilomatricoma, somatic 132600
    DISEASE ASSOCIATED WITH ctnnb1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of dorsal/ventral asymmetry (more)
    Cellular Component adherens junction (more)
    Molecular Function cadherin binding (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Repeat IPR000225 Armadillo
    Homologous_superfamily IPR011989 Armadillo-like helical
    Family IPR013284 Beta-catenin
    Homologous_superfamily IPR016024 Armadillo-type fold
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ctnnb1-201 (1)    Ensembl 3558
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab3-ctnnb1 monoclonal IgG1 , k Mouse IHC, WB Millipore
    4
    Ab2-ctnnb1 polyclonal Rabbit IHC, WB Sigma-Aldrich
    25
    Ab1-ctnnb1 monoclonal IgG1 , k Mouse IHC Life Technologies (Invitrogen)
    2
    Ab2-ctnnb monoclonal IgG1 Mouse IHC, WB BD Biosciences
    24
    CONSTRUCTS WITH SEQUENCES FROM ctnnb1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:cactnnb1-2A-MKATE2,myl7:EGFP) myl7UAS 2Actnnb1EGFPMKATE2 Danio rerio 1 2
    Tg(UAS:ctnnb1-RFP) UAS ctnnb1RFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    ctnnb1 Contained in: [BAC] CH73-49B13 (1)
    ctnnb1 Contains: [SNP] rs3728768 (1)
    ctnnb1 Encodes: [EST] fb73e10 (1), fi81c06 (1), fk25h01, ibd2058
    [cDNA] MGC:56048 (1)
    ctnnb1 Has Artifact: [EST] fj58f01
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131059 (1) 3375 bp
    Genomic GenBank:AL845513 (1) 164117 bp
    Select Tool
    Polypeptide UniProtKB:A0A5H1ZRJ2 (1) 789 aa
    Sequence Information (all 24)
    ORTHOLOGY for ctnnb1 ( Chr: 16 )
    CITATIONS (159)