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ZIRC
ZFIN ID: ZDB-GENE-050518-2
Gene Name: low density lipoprotein receptor-related protein 5
Gene Symbol: lrp5    Nomenclature History

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Previous Name: LRP6

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in animal organ development; canonical Wnt signaling pathway; and sensory perception of sound. Predicted to localize to the plasma membrane and receptor complex. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Is expressed in several structures, including brain; head; pectoral fin bud; posterior lateral line primordium; and tail bud. Orthologous to human LRP5 (LDL receptor related protein 5).
Genome Resources: Alliance (1),  Gene:568518 (1),  Ensembl(GRCz11):ENSDARG00000006921 (2)
DISEASE ASSOCIATED WITH lrp5 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant endosteal hyperostosis Alliance Hyperostosis, endosteal 144750
Osteosclerosis 144750
autosomal dominant osteopetrosis 1 Alliance Osteopetrosis, autosomal dominant 1 607634
exudative vitreoretinopathy 4 Alliance Exudative vitreoretinopathy 4 601813
osteoporosis Alliance {Osteoporosis} 166710
osteoporosis-pseudoglioma syndrome Alliance Osteoporosis-pseudoglioma syndrome 259770
Worth's syndrome Alliance van Buchem disease, type 2 607636
Polycystic liver disease 4 with or without kidney cysts 617875
[Bone mineral density variability 1] 601884
DISEASE ASSOCIATED WITH lrp5 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
nonsyndromic deafness WT + MO5-lrp5 + MO6-lrp5 standard conditions Xia et al., 2017
GENE ONTOLOGY
Ontology GO Term
Biological Process liver development (more)
Cellular Component integral component of membrane (more)
Molecular Function Wnt-activated receptor activity (more)
GO Terms (all 14)
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM lrp5 No data available
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001177458 (1) 4390 bp
Genomic GenBank:FO704597 (1) 86457 bp
Select Tool
Polypeptide UniProtKB:F1QTJ4 (1) 1615 aa
Sequence Clusters UniGene:105028 (1)
Sequence Information (all 20)
ORTHOLOGY for lrp5 ( Chr: 25 )
CITATIONS (31)