Gene

lrp5

ID

ZDB-GENE-050518-2

Name

low density lipoprotein receptor-related protein 5

Symbol

lrp5 Nomenclature History

Previous Names

LRP6

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in animal organ development; canonical Wnt signaling pathway; and sensory perception of sound. Predicted to localize to plasma membrane and receptor complex. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Is expressed in several structures, including brain; head; pectoral fin bud; posterior lateral line primordium; and tail bud. Orthologous to human LRP5 (LDL receptor related protein 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 21 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lrp5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant osteopetrosis 1	Alliance	Osteopetrosis, autosomal dominant 1	607634
exudative vitreoretinopathy 4	Alliance	Exudative vitreoretinopathy 4	601813
osteoporosis-pseudoglioma syndrome	Alliance	Osteoporosis-pseudoglioma syndrome	259770
polycystic liver disease 4	Alliance	Polycystic liver disease 4 with or without kidney cysts	617875
Worth syndrome	Alliance	Endosteal hyperostosis	144750
		[Bone mineral density variability 1]	601884

Associated With lrp5 Via Experimental Models

Human Disease	Fish	Conditions	Citations
osteoporosis	AB + CRISPR3-lrp5	control	Bek et al., 2021
osteoporosis	lrp5^{sa11097/sa11097} (AB)	standard conditions	Bek et al., 2021
nonsyndromic deafness	WT + MO5-lrp5 + MO6-lrp5	standard conditions	Xia et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000742	EGF-like domain
Family	IPR050778	Cueball/EGF/LRP/Nidogen
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Repeat	IPR000033	LDLR class B repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	Cueball/EGF/LRP/Nidogen	EGF-like domain	LDLR class B repeat	LDL receptor-like superfamily	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	Six-bladed beta-propeller, TolB-like
UniProtKB:D0EWS1 InterPro	1430
UniProtKB:A0A8M3AZI2 InterPro	1613
UniProtKB:F1QTJ4 InterPro	1615

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lrp5-201 (1) Ensembl	Ensembl	9,019 nt	Select Tool ZFIN BLAST
mRNA	lrp5-202 (1) Ensembl	Ensembl	4,390 nt	Select Tool ZFIN BLAST
mRNA	lrp5-203 (1) Ensembl	Ensembl	6,388 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations