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ZIRC
ZFIN ID: ZDB-GENE-000403-2
Gene Name: axin 2 (conductin, axil)
Gene Symbol: axin2    Nomenclature History

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Previous Names: axil, etID37069.3 (1), wu:fb37c08 (1), zgc:111942

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Involved in dorsal/ventral axis specification and negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma. Is expressed in several structures, including anterior neural keel; digestive system; marginal blastomere; nervous system; and pharyngeal arch. Orthologous to human AXIN2 (axin 2).
Genome Resources: Alliance (1),  Gene:58080 (1),  Ensembl(GRCz11):ENSDARG00000100149 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa40180 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40181 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45159 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-axin2 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH axin2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    Oligodontia-colorectal cancer syndrome 608615
    DISEASE ASSOCIATED WITH axin2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal/ventral pattern formation (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein binding (more)
    GO Terms (all 7)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA axin2-202 (1)    Ensembl 3515
    ncRNA axin2-002 (1) 1429
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM axin2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:axin2-EGFP) hsp70l axin2EGFP Danio rerio 1 2
    TgBAC(axin2:Venus) axin2 Venus Danio rerio 1 2
    MARKER RELATIONSHIPS
    axin2 Contained in: [BAC] CH211-196B14 (1) (order this)
    axin2 Encodes: [EST] eu48 (1), fb37c08 (1), IMAGE:3818167 (1) (order this)
    [cDNA] MGC:111942 (1) (order this), MGC:195290 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131561 (1) 3485 bp
    Genomic GenBank:BX088708 (1) 193659 bp
    Select Tool
    Polypeptide UniProtKB:B3DKI7 (1) 812 aa
    Sequence Clusters UniGene:3727 (1)
    Sequence Information (all 29)
    ORTHOLOGY for axin2 ( Chr: 3 )
    CITATIONS (158)