Gene
axin2
- ID
- ZDB-GENE-000403-2
- Name
- axin 2 (conductin, axil)
- Symbol
- axin2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including I-SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification. Acts upstream of or within dorsal/ventral axis specification and heart development. Predicted to be located in cytoplasm. Predicted to be part of beta-catenin destruction complex. Predicted to be active in nucleus and plasma membrane. Is expressed in several structures, including anterior neural keel; marginal blastomere; nervous system; pharyngeal arch; and pleuroperitoneal region. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma; gastrointestinal system cancer (multiple); lung cancer (multiple); and orofacial cleft. Orthologous to human AXIN2 (axin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 95 figures from 73 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:3818167 (27 images)
- eu48 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhu et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| Oligodontia-colorectal cancer syndrome | 608615 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital heart disease | AB + MO1-axin2 | standard conditions | Zhu et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001158 | DIX domain |
| Domain | IPR014936 | Axin beta-catenin binding |
| Domain | IPR016137 | RGS domain |
| Domain | IPR032101 | Axin-1/2, tankyrase-binding domain |
| Family | IPR043581 | Axin-like |
| Homologous_superfamily | IPR024066 | RGS, subdomain 1/3 |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036305 | RGS domain superfamily |
| Homologous_superfamily | IPR038207 | DIX domain superfamily |
| Homologous_superfamily | IPR044926 | RGS, subdomain 2 |
Domain Details Per Protein
| Protein | Length | Axin-1/2, tankyrase-binding domain | Axin beta-catenin binding | Axin-like | DIX domain | DIX domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 1/3 | RGS, subdomain 2 | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:P57095
|
812 |
Interactions and Pathways
No data available
Plasmids