Gene

axin2

ID
ZDB-GENE-000403-2
Name
axin 2 (conductin, axil)
Symbol
axin2 Nomenclature History
Previous Names
  • axil
  • etID37069.3 (1)
  • wu:fb37c08 (1)
  • zgc:111942
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Involved in dorsal/ventral axis specification; heart development; and negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification. Predicted to localize to cytoplasm. Is expressed in several structures, including anterior neural keel; digestive system; marginal blastomere; nervous system; and pharyngeal arch. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in colorectal cancer and endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2).
Genome Resources
Note
None
Expression
All Expression Data
76 figures from 56 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 4 from Zhu et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With axin2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
colorectal cancer Alliance Colorectal cancer, somatic 114500
Oligodontia-colorectal cancer syndrome 608615
Associated With axin2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001158 DIX domain
Domain IPR014936 Axin beta-catenin binding
Domain IPR016137 RGS domain
Domain IPR032101 Axin-1/2, tankyrase-binding domain
Family IPR043581 Axin-like
Homologous_superfamily IPR024066 RGS, subdomain 1/3
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR036305 RGS domain superfamily
Homologous_superfamily IPR038207 DIX domain superfamily
Domain Details Per Protein
Protein Length Axin-1/2, tankyrase-binding domain Axin beta-catenin binding Axin-like DIX domain DIX domain superfamily RGS domain RGS domain superfamily RGS, subdomain 1/3 Ubiquitin-like domain superfamily
UniProtKB:P57095 812
UniProtKB:Q7ZW51 268
UniProtKB:B3DKI7 812
UniProtKB:Q502Q2 321
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations