ZFIN ID: ZDB-GENE-990714-4
Gene Name: glycogen synthase kinase 3 beta, genome duplicate a
Gene Symbol: gsk3ba    Nomenclature History

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Previous Names: GSK-3[b] (1), gsk3b, fb68h05, fk80d11, wu:fb68h05 (1), wu:fk80d11 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have beta-catenin binding activity; protein kinase activity; and protein kinase binding activity. Involved in angiogenesis; heart jogging; and heart looping. Predicted to localize to several cellular components, including the axon; beta-catenin destruction complex; and glutamatergic synapse. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Is expressed in ovary and testis. Orthologous to human GSK3B (glycogen synthase kinase 3 beta).
Genome Resources: Alliance (1),  Gene:30654 (1),  Ensembl(GRCz11):ENSDARG00000017803 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
f136jy Small Deletion Unknown Unknown CRISPR
f137jy Insertion Unknown Unknown CRISPR
la029640Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gsk3ba 3
    MO1-gsk3ba N/A 5
    MO2-gsk3ba N/A 1
    TALEN1-gsk3ba
    2
    DISEASE ASSOCIATED WITH gsk3ba HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH gsk3ba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component axon (more)
    Molecular Function ATP binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Binding_site IPR017441 Protein kinase, ATP binding site
    Family IPR033573 Glycogen synthase kinase-3 beta
    Domain IPR039192 Glycogen synthase kinase 3, catalytic domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gsk3b-201 (1)    Ensembl 4420
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM gsk3ba No data available
    MARKER RELATIONSHIPS
    gsk3ba Contained in: [BAC] DKEY-32O22 (1) (order this)
    gsk3ba Encodes: [EST] fb68h05, fk80d11 (1)
    [cDNA] MGC:194027 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131381 (1) 2624 bp
    Genomic GenBank:CR759880 (1) 183450 bp
    Select Tool
    Polypeptide UniProtKB:Q9IBD2 (1) 421 aa
    Sequence Information (all 19)
    ORTHOLOGY for gsk3ba ( Chr: 9 )
    CITATIONS (63)