Gene

gsk3ba

ID
ZDB-GENE-990714-4
Name
glycogen synthase kinase 3 beta, genome duplicate a
Symbol
gsk3ba Nomenclature History
Previous Names
  • GSK-3[b] (1)
  • gsk3b
  • fb68h05
  • fk80d11
  • wu:fb68h05 (1)
  • wu:fk80d11 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have beta-catenin binding activity; protein serine/threonine kinase activity; and tau-protein kinase activity. Involved in angiogenesis; heart jogging; and heart looping. Predicted to localize to several cellular components, including axon; beta-catenin destruction complex; and glutamatergic synapse. Is expressed in ovary and testis. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gsk3ba Human Ortholog
No data available
Associated With gsk3ba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR039192 Glycogen synthase kinase 3, catalytic domain
Family IPR033573 Glycogen synthase kinase-3 beta
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Glycogen synthase kinase-3 beta Glycogen synthase kinase 3, catalytic domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q9IBD2 421
UniProtKB:Q9YH60 421
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations