ZFIN ID: ZDB-GENE-990715-1
Gene Name: frizzled related protein
Gene Symbol: frzb    Nomenclature History

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Previous Names: cb291 (1), fzb1, id:ibd5075, ik:tdsubc_2e7 (1), sfrp3 (1), xx:tdsubc_2e7

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have Wnt-protein binding activity. Involved in chondrocyte proliferation. Predicted to localize to cytoplasm and extracellular space. Is expressed in several structures, including germ ring; head; hypochord; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein).
Genome Resources: Alliance (1),  Gene:30119 (1),  Ensembl(GRCz11):ENSDARG00000018383 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
zf755 Small Deletion Unknown Unknown CRISPR
zf756 Indel Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-frzb 1
MO1-frzb N/A 1
MO2-frzb N/A 1
MO3-frzb N/A 1
DISEASE ASSOCIATED WITH frzb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Osteoarthritis susceptibility 1} 165720
DISEASE ASSOCIATED WITH frzb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process chondrocyte proliferation (more)
Cellular Component extracellular region (more)
Molecular Function Wnt-protein binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA frzb-201 (1)    Ensembl 2994
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM frzb No data available
MARKER RELATIONSHIPS
frzb Contained in: [BAC] DKEY-234N3 (1) (order this)
frzb Encodes: [EST] cb291 (1) (order this), ibd5075, tdsubc_2e7
[cDNA] MGC:194362 (1), MGC:194385 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_130943 (1) 948 nt
Genomic GenBank:CR513785 (1) 141682 nt
Select Tool
Polypeptide UniProtKB:A0A0B5JQ70 (1) 315 aa
Sequence Information (all 23)
ORTHOLOGY for frzb ( Chr: 9 )
CITATIONS (46)