Gene

frzb

ID

ZDB-GENE-990715-1

Name

frizzled related protein

Symbol

frzb Nomenclature History

Previous Names

cb291 (1)
fzb1
id:ibd5075
ik:tdsubc_2e7 (1)
sfrp3 (1)
xx:tdsubc_2e7

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable Wnt-protein binding activity. Acts upstream of or within chondrocyte proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including germ ring; head; hypochord; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

23 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb291 (37 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With frzb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Osteoarthritis susceptibility 1}	165720

Associated With frzb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001134	Netrin domain
Domain	IPR018933	Netrin module, non-TIMP type
Domain	IPR020067	Frizzled domain
Domain	IPR035813	Secreted frizzled-related protein 3, NTR domain
Domain	IPR041759	SFRP3, cysteine-rich domain
Family	IPR015526	Frizzled/secreted frizzled-related protein
Homologous_superfamily	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily	IPR036790	Frizzled cysteine-rich domain superfamily