Gene
frzb
- ID
- ZDB-GENE-990715-1
- Name
- frizzled related protein
- Symbol
- frzb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable Wnt-protein binding activity. Acts upstream of or within chondrocyte proliferation and vasculature development. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including corpuscles of Stannius; germ ring; head; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb291 (37 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-frzb | Rochard et al., 2016 | |
| MO1-frzb | N/A | (2) |
| MO2-frzb | N/A | Lu et al., 2011 |
| MO3-frzb | N/A | (2) |
| MO4-frzb | N/A | Oh et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Osteoarthritis susceptibility 1} | 165720 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001134 | Netrin domain |
| Domain | IPR018933 | Netrin module, non-TIMP type |
| Domain | IPR020067 | Frizzled domain |
| Domain | IPR035813 | Secreted frizzled-related protein 3, NTR domain |
| Domain | IPR041759 | SFRP3, cysteine-rich domain |
| Family | IPR015526 | Frizzled/secreted frizzled-related protein |
| Homologous_superfamily | IPR008993 | Tissue inhibitor of metalloproteinases-like, OB-fold |
| Homologous_superfamily | IPR036790 | Frizzled cysteine-rich domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Netrin domain | Netrin module, non-TIMP type | Secreted frizzled-related protein 3, NTR domain | SFRP3, cysteine-rich domain | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W6E0 | InterPro | 315 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-234N3 | ZFIN Curated Data | |
| Encodes | EST | cb291 | Thisse et al., 2001 | |
| Encodes | EST | ibd5075 | ||
| Encodes | EST | tdsubc_2e7 | ||
| Encodes | cDNA | MGC:194362 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194385 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130943 (1) | 2599 nt | ||
| Genomic | GenBank:CR513785 (2) | 141682 nt | ||
| Polypeptide | UniProtKB:Q9W6E0 (1) | 315 aa |
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Chen, X., Liu, F., Chen, K., Wang, Y., Yin, A., Kang, X., Yang, S., Zhao, H., Dong, S., Li, Y., Chen, J., Wu, Y. (2022) TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS neuroscience & therapeutics. 28(12):2076-2089
- Shin, K., Begeman, I.J., Cao, J., Kang, J. (2022) leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(1):91-106
- Sun, J., Peterson, E.A., Wang, A.Z., Ou, J., Smith, K.E., Poss, K.D., Wang, J. (2022) hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration. Circulation. 146(1):48-63
- Klingbeil, K., Nguyen, T., Fahrner, A., Guthmann, C., Wang, H., Schoels, M., Lilienkamp, M., Franz, H., Eckert, P., Walz, G., Yakulov, T.A. (2021) Corpuscles of Stannius development requires FGF signaling. Developmental Biology. 481:160-171
- Wu, X., Zhang, H., Zhang, B., Zhang, Y., Wang, Q., Shen, W., Wu, X., Li, L., Xia, W., Nakamura, R., Liu, B., Liu, F., Takeda, H., Meng, A., Xie, W. (2021) Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs. Science advances. 7:eabl3858
- Carroll, S.H., Macias Trevino, C., Li, E.B., Kawasaki, K., Myers, N., Hallett, S.A., Alhazmi, N., Cotney, J., Carstens, R.P., Liao, E.C. (2020) An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development (Cambridge, England). 147(24):
- Gao, X., Huang, S.S., Qiu, S.W., Su, Y., Wang, W.Q., Xu, H.Y., Xu, J.C., Kang, D.Y., Dai, P., Yuan, Y.Y. (2020) Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms. Journal of Medical Genetics. 58(7):465-474
- He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., Sun, Y. (2020) Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLoS Biology. 18:e3000561
- Oh, C.K., Ko, Y., Park, J.J., Heo, H.J., Kang, J., Kwon, E.J., Kang, J.W., Lee, Y., Myung, K., Kang, J.M., Ko, D.S., Kim, Y.H. (2020) FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity. Bioscience Reports. 41(1):
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