ZFIN ID: ZDB-GENE-020711-1
Gene Name: MYCN proto-oncogene, bHLH transcription factor
Gene Symbol: mycn    Nomenclature History

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Previous Names: N-myc (1), fb57a02 (1), nmyc1 (1), wu:fb57a02 (1), zgc:85706 (1), zN-myc (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Feingold syndrome. Is expressed in several structures, including immature eye; nervous system; pectoral fin bud; pharyngeal arch; and pronephric duct. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor).
Genome Resources: Alliance (1),  Gene:252851 (1),  Ensembl(GRCz11):ENSDARG00000006837 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1804 Point Mutation Unknown Missense ENU
sa13838 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mycn HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Feingold syndrome Alliance Feingold syndrome 1 164280
    DISEASE ASSOCIATED WITH mycn VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component host cell nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mycn-201 (1)    Ensembl 2488
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mycn No data available
    MARKER RELATIONSHIPS
    mycn Contained in: [BAC] DKEY-161F12 (order this)
    mycn Encodes: [EST] fb57a02
    [cDNA] MGC:85706
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212614 (1) 2490 nt
    Genomic GenBank:BX005358 (1) 181198 nt
    Select Tool
    Polypeptide UniProtKB:A0A0A0MPF8 (1) 503 aa
    Sequence Information (all 22)
    ORTHOLOGY for mycn ( Chr: 20 )
    CITATIONS (48)