Fig. 7

Schematic diagram on the function of glial betaPix in zebrafish vascular integrity development of the hindbrain. betaPix is enriched in glia and regulates the PAK1-Stathmin axis on microtubulin stabilization, thus fine-tuning glial cell migration and their interactions with vascular endothelial cells; and in parallel, betaPix may also regulate Zfhx3/4-Vegfaa signaling in glia, which then modulates angiogenesis during cerebral vessel development and maturation. Deletion of betaPix affects glial cell migration and interaction with cerebral endothelial cells. MT, microtubule.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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