FIGURE

Figure 6

ID

ZDB-FIG-251226-12

Publication

Fan et al., 2025 - Bcl3 Deficiency Leads to Hyperinflammation in Zebrafish

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Figure 6

Effects of Dex treatment in bcl3^−/− larvae. (A) Survival curve of WT and bcl3^−/⁻ larvae upon LPS injection followed by Dex immersion, analyzed using the log-rank (Mantel–Cox) test. Relative mRNA expression of (B) pro-inflammatory genes il1b, il6, il8, and tnfa, and (C) antiviral genes ifn1, ifn3, mxc, and pkz in WT and bcl3^−/⁻ larvae at 48 h upon LPS injection followed by Dex immersion. The data was analyzed from three independent experiments performed in triplicate. Statistical significance was assessed using one-way ANOVA followed by Tukey’s post hoc test. *** p < 0.001, ** p < 0.01, * p < 0.05, ns indicates not significant. Error bars represent SD.

Expression Data

Genes:	cxcl8a ifnphi1 ifnphi3 il1b il6 mxc pkz tnfa
Fish:	AB bcl3^{umo201/umo201} (AB)
Conditions:	chemical treatment by injection: lipopolysaccharide chemical treatment by injection: lipopolysaccharide
Anatomical Term:	whole organism
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB bcl3^{umo201/umo201} (AB)
Conditions:	chemical treatment by injection: lipopolysaccharide chemical treatment by injection: lipopolysaccharide
Observed In:	whole organism
Stage Range:	Day 6 to Days 7-13

Phenotype Detail

Acknowledgments

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