ZFIN ID: ZDB-GENE-050317-1
Gene Name: tumor necrosis factor a (TNF superfamily, member 2)
Gene Symbol: tnfa    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: TNF1 (1), TNF-alpha 1 (1), tnf-alpha

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have cytokine activity and tumor necrosis factor receptor binding activity. Involved in several processes, including fin regeneration; intestinal epithelial structure maintenance; and response to bacterium. Predicted to localize to extracellular space and integral component of membrane. Is expressed in several structures, including digestive system; heart; male organism; pleuroperitoneal region; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to several human genes including LTA (lymphotoxin alpha).
Genome Resources: Alliance (1),  Gene:405785 (1),  Ensembl(GRCz11):ENSDARG00000009511 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb497 Indel Exon 1 Unknown CRISPR
sa16250 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43296 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tnfa
    1
    CRISPR2-tnfa
    1
    CRISPR3-tnfa
    1
    CRISPR4-tnfa
    1
    CRISPR5-tnfa 1
    MO1-tnfa N/A 3
    MO2-tnfa N/A 1
    MO3-tnfa N/A 2
    MO4-tnfa N/A 9
    MO5-tnfa N/A 1
    MO6-tnfa N/A 1
    DISEASE ASSOCIATED WITH tnfa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    asthma Alliance {Asthma, susceptibility to} 600807
    migraine Alliance {Migraine without aura, susceptibility to} 157300
    {Dementia, vascular, susceptibility to}
    {Malaria, cerebral, susceptibility to} 611162
    {Septic shock, susceptibility to}
    DISEASE ASSOCIATED WITH tnfa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process defense response to bacterium (more)
    Cellular Component integral component of membrane (more)
    Molecular Function tumor necrosis factor receptor binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tnfa-201 (1)    Ensembl 1048
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tnfa polyclonal IgG Rabbit IHC AnaSpec
    12
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tnfa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(tnfa:EGFPF) tnfa EGFP Danio rerio 1 8
    Tg(tnfa:emGFP) tnfa emGFP Danio rerio 1 1
    TgBAC(tnfa:GFP) tnfa GFP Danio rerio 1 22
    MARKER RELATIONSHIPS
    tnfa Contained in: [BAC] CH73-361O3 (1), CH211-127D20 (1), CH211-176D22 (1)
    tnfa Encodes: [cDNA] MGC:152825 (1), MGC:192241 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212859 (1) 1145 nt
    Genomic GenBank:BX469886 151598 nt
    Select Tool
    Polypeptide UniProtKB:Q08CQ3 (1) 234 aa
    Sequence Information (all 18)
    ORTHOLOGY for tnfa ( Chr: 19 )
    CITATIONS (473)