Gene
tnfa
- ID
- ZDB-GENE-050317-1
- Name
- tumor necrosis factor a (TNF superfamily, member 2)
- Symbol
- tnfa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity and tumor necrosis factor receptor binding activity. Involved in several processes, including fin regeneration; intestinal epithelial structure maintenance; and response to bacterium. Predicted to localize to extracellular space and integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Is expressed in several structures, including heart; integument; liver; male organism; and pleuroperitoneal region. Orthologous to several human genes including LTA (lymphotoxin alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 250 figures from 193 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| asthma | Alliance | {Asthma, susceptibility to} | 600807 |
| migraine | Alliance | {Migraine without aura, susceptibility to} | 157300 |
| ?Immunodeficiency 127 | 620977 | ||
| {Dementia, vascular, susceptibility to} | |||
| {Malaria, cerebral, susceptibility to} | 611162 | ||
| {Septic shock, susceptibility to} |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Lymphotoxin-alpha | Tumour necrosis factor | Tumour necrosis factor domain | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q1L8A5
|
234 | ||||
|
UniProtKB:Q08CQ3
|
234 |
Interactions and Pathways
No data available
Plasmids
No data available