FIGURE

Figure 3

ID

ZDB-FIG-251226-9

Publication

Fan et al., 2025 - Bcl3 Deficiency Leads to Hyperinflammation in Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Figure 3

Histological abnormalities and reduced immune cell marker expression in bcl3^−/− zebrafish. (A) H&E-stained sections of thymus from WT and bcl3^−/⁻ zebrafish at 4 months of age. Green arrows indicate Hassall bodies. (B) H&E-stained sections of liver from WT and bcl3^−/⁻ zebrafish. Black arrows indicate hepatocytes with nuclear displacement and pyknosis. Relative mRNA expression of (C) rag2 (T cell marker), (D) mpeg1 (macrophage marker), (E) cd79a (B cell marker), and (F) mpx (neutrophil marker) in the liver, spleen, and kidney of bcl3^+/+ and bcl3^−/− zebrafish at 4 months of age. *** p < 0.001, ** p < 0.01, * p < 0.05 (t-test), ns indicates not significant. Error bars represent SD.

Expression Data

Genes:	cd79a mpeg1.1 mpx rag2
Fish:	AB bcl3^{umo201/umo201} (AB)
Anatomical Terms:	kidney liver spleen
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bcl3^{umo201/umo201} (AB)
Observed In:	hepatocyte chromatin hepatocyte nucleus kidney liver spleen thymus
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cells