Gene
il6
- ID
- ZDB-GENE-120509-1
- Name
- interleukin 6 (interferon, beta 2)
- Symbol
- il6 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including bone tissue; epidermis; heart; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); liver disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 125 figures from 101 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| arteriovenous malformations of the brain | Alliance | {Intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to} | 108010 |
| inflammatory bowel disease 1 | Alliance | {Crohn disease-associated growth failure} | 266600 |
| juvenile rheumatoid arthritis | Alliance | {Rheumatoid arthritis, systemic juvenile} | 604302 |
| type 1 diabetes mellitus | Alliance | {Type 1 diabetes mellitus} | 222100 |
| type 2 diabetes mellitus | Alliance | {Type 2 diabetes mellitus} | 125853 |
| {Kaposi sarcoma in HIV+, susceptibility to} | 148000 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Interleukin-6-like |
|---|---|---|---|---|
| UniProtKB:H9A0J9 | InterPro | 231 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available