Gene
il6
- ID
- ZDB-GENE-120509-1
- Name
- interleukin 6 (interferon, beta 2)
- Symbol
- il6 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity and interleukin-6 receptor binding activity. Involved in hematopoietic stem cell differentiation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Is expressed in several structures, including epidermis; immune system; lateral line; liver; and peripheral olfactory organ. Orthologous to human IL6 (interleukin 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 65 figures from 54 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| arteriovenous malformations of the brain | Alliance | {Intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to} | 108010 |
| inflammatory bowel disease 1 | Alliance | {Crohn disease-associated growth failure} | 266600 |
| juvenile rheumatoid arthritis | Alliance | {Rheumatoid arthritis, systemic juvenile} | 604302 |
| type 1 diabetes mellitus | Alliance | {Type 1 diabetes mellitus} | 222100 |
| type 2 diabetes mellitus | Alliance | {Type 2 diabetes mellitus} | 125853 |
| {Kaposi sarcoma, susceptibility to} | 148000 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Four-helical cytokine-like, core | Interleukin-6 | Interleukin-6/GCSF/MGF |
|---|---|---|---|---|
|
UniProtKB:H9A0J9
|
231 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available