FIGURE

Figure 5

ID

ZDB-FIG-251226-11

Publication

Fan et al., 2025 - Bcl3 Deficiency Leads to Hyperinflammation in Zebrafish

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Figure 5

Immune responses upon LPS and poly(I:C) stimulation in bcl3^−/− larvae. Representative morphology of (A) WT and (B) bcl3^−/− larvae under untreated condition or at 24 h upon LPS or poly(I:C) injection. Relative mRNA expression of (C) pro-inflammatory genes il1b, il6, il8, and tnfa and anti-inflammatory gene il10, and (D) antiviral genes ifn1, ifn3, mxc, and pkz in WT and bcl3^−/⁻ larvae 24 h upon LPS or poly(I:C) injection. The data was analyzed from three independent experiments performed in triplicate. *** p < 0.001, ** p < 0.01, * p < 0.05 (t-test). Error bars represent SD.

Expression Data

Genes:	cxcl8a fndc1 il1b il6 il10 mxc pkz tnfa
Fish:	AB bcl3^{umo201/umo201} (AB)
Conditions:	chemical treatment by injection: lipopolysaccharide chemical treatment by injection: poly(I:C)
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB bcl3^{umo201/umo201} (AB)
Conditions:	chemical treatment by injection: lipopolysaccharide chemical treatment by injection: poly(I:C)
Observed In:	pericardium swim bladder whole organism yolk
Stage:	Day 5

Phenotype Detail

Acknowledgments

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