FIGURE

Figure 7

ID

ZDB-FIG-251226-13

Publication

Fan et al., 2025 - Bcl3 Deficiency Leads to Hyperinflammation in Zebrafish

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Figure 7

Effects of Dex treatment in adult bcl3^−/− zebrafish. (A) Survival curve of WT and bcl3^−/⁻ zebrafish with Dex injection, analyzed using the log-rank (Mantel–Cox) test. Relative mRNA expression of pro-inflammatory genes il1b, il6, il8, and tnfa in (B) liver, (C) spleen, and (D) muscle of WT and bcl3^−/− zebrafish upon Dex treatment. The data was analyzed from three independent experiments performed in triplicate. Statistical significance was assessed using one-way ANOVA followed by Tukey’s post hoc test. *** p < 0.001 ** p < 0.01, * p < 0.05, ns indicates not significant. Error bars represent SD.

Expression Data

Genes:	cxcl8a il1b il6 tnfa
Fish:	AB bcl3^{umo201/umo201} (AB)
Condition:	chemical treatment by injection: dexamethasone
Anatomical Terms:	liver muscle spleen
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bcl3^{umo201/umo201} (AB)
Condition:	chemical treatment by injection: dexamethasone
Observed In:	liver muscle spleen whole organism
Stage Range:	Days 45-89 to Adult

Phenotype Detail

Acknowledgments

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