Gene
cxcl8a
- ID
- ZDB-GENE-081104-317
- Name
- chemokine (C-X-C motif) ligand 8a
- Symbol
- cxcl8a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables chemokine activity. Acts upstream of or within several processes, including blood vessel morphogenesis; endothelial to hematopoietic transition; and hematopoietic stem cell differentiation. Predicted to be located in extracellular space. Is expressed in several structures, including cardiovascular system; eye; integument; liver; and pleuroperitoneal region. Used to study vitamin D-dependent rickets. Human ortholog(s) of this gene implicated in several diseases, including acute pyelonephritis; adult respiratory distress syndrome; carcinoma (multiple); gastritis (multiple); and pulmonary fibrosis (multiple). Orthologous to several human genes including CXCL2 (C-X-C motif chemokine ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 90 figures from 65 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| vitamin D-dependent rickets | cxcl8auwm25/uwm25 | standard conditions | Cortes et al., 2016 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Chemokine beta/gamma/delta | Chemokine interleukin-8-like domain | Chemokine interleukin-8-like superfamily | CXC chemokine | CXC Chemokine domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0G2KYH9 | InterPro | ||||||
| UniProtKB:A0A8M3B7M3 | InterPro | 97 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcl8a-201
(1)
|
Ensembl | 716 nt |
Interactions and Pathways
No data available
Plasmids
No data available