ZFIN ID: ZDB-GENE-081104-317
Gene Name: chemokine (C-X-C motif) ligand 8a
Gene Symbol: cxcl8a    Nomenclature History

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Previous Names: cxcl8, il8 (1), cxcl-chr1a (1), cxcl-chr1b (1), CXCL8_L1_chr1 (1), dr-chr1-CXCL8 (1), si:dkey-151b16.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Exhibits chemokine activity. Involved in several processes, including blood vessel morphogenesis; endothelial to hematopoietic transition; and leukocyte migration. Predicted to localize to extracellular space. Is expressed in several structures, including cardiovascular system; eye; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to several human genes including CXCL8 (C-X-C motif chemokine ligand 8).
Genome Resources: Alliance (1),  Gene:100002946 (1),  Ensembl(GRCz11):ENSDARG00000104795 (1)
GENE EXPRESSION
All Expression Data: 57 figures from 40 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
uwm25 Small Deletion Unknown Unknown TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-cxcl8a N/A 4
MO2-cxcl8a N/A 1
MO3-cxcl8a N/A 1
MO4-cxcl8a N/A 3
MO5-cxcl8a N/A 4
MO6-cxcl8a N/A 1
TALEN1-cxcl8a 1
DISEASE ASSOCIATED WITH cxcl8a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH cxcl8a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process angiogenesis (more)
Cellular Component extracellular region (more)
Molecular Function chemokine activity (more)
GO Terms (all 28)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cxcl8a No data available
MARKER RELATIONSHIPS
cxcl8a Contained in: [BAC] DKEY-151B16 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_001342570 (1)
Genomic GenBank:CT826376 (1) 164364 nt
Select Tool
Polypeptide UniProtKB:A0A0G2KYH9 (1)
Sequence Information (all 8)
ORTHOLOGY for cxcl8a ( Chr: 1 )
CITATIONS (217)