Gene
pkz
- ID
- ZDB-GENE-050301-2
- Name
- protein kinase containing Z-DNA binding domains
- Symbol
- pkz Nomenclature History
- Previous Names
-
- zgc:136657
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Exhibits left-handed Z-DNA binding activity and protein kinase activity. Predicted to be involved in protein phosphorylation. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and Parkinson's disease. Is expressed in several structures, including digestive system; eye; heart; musculature system; and pleuroperitoneal region. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR042371 | Z-binding domain |
| Family | IPR050339 | Cell Cycle and Stress Response Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Cell Cycle and Stress Response Kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily | Z-binding domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5NE14
|
511 | ||||||||
|
UniProtKB:Q5NE12
|
511 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available