Gene

il1b

ID
ZDB-GENE-040702-2
Name
interleukin 1, beta
Symbol
il1b Nomenclature History
Previous Names
  • zgc:111873
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have cytokine activity; interleukin-1 receptor antagonist activity; and interleukin-1 receptor binding activity. Involved in several processes, including fin regeneration; leukocyte chemotaxis; and response to bacterium. Predicted to localize to extracellular space. Is expressed in several structures, including brain; liver; male organism; pleuroperitoneal region; and trunk. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta).
Genome Resources
Note
None
Expression
All Expression Data
174 figures from 124 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. S2 from Ogryzko et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary diffuse gastric cancer Alliance {Gastric cancer risk after H. pylori infection} 137215
Associated With il1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020877 Interleukin-1 conserved site
Family IPR000975 Interleukin-1 family
Family IPR039348 Interleukin-1 receptor antagonist
Homologous_superfamily IPR008996 Cytokine IL1/FGF
Domain Details Per Protein
Protein Length Cytokine IL1/FGF Interleukin-1 conserved site Interleukin-1 family Interleukin-1 receptor antagonist
UniProtKB:A0A2R8QIV9 272
UniProtKB:E0WCW4 281
UniProtKB:E6N152 272
UniProtKB:A0A2R8QPM3 273
UniProtKB:A0A0R4IYF1 284
UniProtKB:Q4KMF1 272
UniProtKB:Q7T056 273
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab4-il1b Rabbit
1
AB3-il1b monoclonal Mouse
  • IHC
1
Ab1-il1b polyclonal Rabbit
  • IHC
  • WB
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations