ZFIN is now using GRCz12tu for Genomic Data
Gene
il1b
- ID
- ZDB-GENE-040702-2
- Name
- interleukin 1, beta
- Symbol
- il1b Nomenclature History
- Previous Names
-
- zgc:111873
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytokine activity. Acts upstream of or within several processes, including fin regeneration; leukocyte chemotaxis; and response to bacterium. Predicted to be located in cytosol; extracellular region; and lysosome. Predicted to be active in extracellular space. Is expressed in several structures, including bone tissue; digestive system; heart; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to several human genes including IL1B (interleukin 1 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 341 figures from 253 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu384 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| stomach cancer | Alliance | {Gastric cancer risk after H. pylori infection} | 613659 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytokine IL1/FGF | Interleukin-1 conserved site | Interleukin-1 family |
|---|---|---|---|---|---|
| UniProtKB:E6N152 | InterPro | 272 | |||
| UniProtKB:A0A8M1PI54 | InterPro | 284 | |||
| UniProtKB:A0AB32U0W0 | InterPro | 284 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers