Gene
il10
- ID
- ZDB-GENE-051111-1
- Name
- interleukin 10
- Symbol
- il10 Nomenclature History
- Previous Names
-
- zgc:194510
- zgc:194518
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within several processes, including regulation of Notch signaling pathway; regulation of intestinal epithelial cell development; and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in blood; digestive system; gill; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 70 figures from 54 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| e46 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ihb422 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| sa1423 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21894 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44739 | Allele with one point mutation | Unknown | Unknown | ENU | |
| uu1751 | Allele with one deletion | Exon 1 | Unknown | not specified | |
| uu1762 | Allele with one delins | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-il10 | Zebrafish Nomenclature Committee | |
| CRISPR2-il10 | (2) | |
| CRISPR3-il10 | (2) | |
| MO1-il10 | N/A | Lu et al., 2024 |
| MO2-il10 | N/A | Niu et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| graft-versus-host disease | Alliance | {Graft-versus-host disease, protection against} | 614395 |
| rheumatoid arthritis | Alliance | {Rheumatoid arthritis, progression of} | 180300 |
| {HIV-1, susceptibility to} | 609423 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Interleukin-10 | Interleukin-10/19/20/24/26 |
|---|---|---|---|---|---|
| UniProtKB:Q5EFQ8 | InterPro | 180 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-158F7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194510 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194518 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020785 (1) | 543 nt | ||
| Genomic | GenBank:CU459075 (2) | 179501 nt | ||
| Polypeptide | UniProtKB:Q5EFQ8 (1) | 180 aa |
- Brenet, A., Somkhit, J., Csaba, Z., Ciura, S., Kabashi, E., Yanicostas, C., Soussi-Yanicostas, N. (2024) Microglia Mitigate Neuronal Activation in a Zebrafish Model of Dravet Syndrome. Cells. 13(8):
- Brix, A., Belleri, L., Pezzotta, A., Pettinato, E., Mazzola, M., Zoccolillo, M., Marozzi, A., Monteiro, R., Del Bene, F., Mortellaro, A., Pistocchi, A. (2024) ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish. Communications biology. 7:615615
- Camussi, D., Naef, V., Brogi, L., Della Vecchia, S., Marchese, M., Nicoletti, F., Santorelli, F.M., Licitra, R. (2024) Delving into the Complexity of Valproate-Induced Autism Spectrum Disorder: The Use of Zebrafish Models. Cells. 13(16):
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Guo, D., Xiong, H., Yang, Z., Zhang, R., Shi, P., Yao, Y., Liu, M., Xu, C., Wang, Q.K. (2024) Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e23870e23870
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
- Lu, C., Hyde, D.R. (2024) Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina. Frontiers in cell and developmental biology. 12:14063301406330
- Martínez-López, M.F., de Almeida, C.R., Fontes, M., Mendes, R.V., Kaufmann, S.H.E., Fior, R. (2024) Macrophages directly kill bladder cancer cells through TNF signaling as an early response to BCG therapy. Disease models & mechanisms. 17(8):
- Niu, K., Zhang, C., Liu, C., Wu, W., Yan, Y., Zheng, A., Liu, S., Shi, Z., Yang, M., Wang, W., Xiao, Q. (2024) An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis. European journal of cell biology. 103:151465151465
- Silva, M.G.F.R., Luchiari, A.C., Medeiros, I., de Souza, A.M., Serquiz, A.C., Martins, F.F., Moura, S.A.B., Camillo, C.S., Medeiros, S.R.B., Pais, T.D.S., Passos, T.S., Galeno, D.M.L., Morais, A.H.A. (2024) Evaluation of the Effects of Diet-Induced Obesity in Zebrafish (Danio rerio): A Comparative Study. Nutrients. 16(19):
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