Gene
il10
- ID
- ZDB-GENE-051111-1
- Name
- interleukin 10
- Symbol
- il10 Nomenclature History
- Previous Names
-
- zgc:194510
- zgc:194518
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within immune response; negative regulation of inflammatory response; and response to bacterium. Predicted to be located in extracellular space. Is expressed in blood; digestive system; gill; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 69 figures from 53 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| graft-versus-host disease | Alliance | {Graft-versus-host disease, protection against} | 614395 |
| rheumatoid arthritis | Alliance | {Rheumatoid arthritis, progression of} | 180300 |
| {HIV-1, susceptibility to} | 609423 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Four-helical cytokine-like, core | Interleukin-10 | Interleukin-10/19/20/24/26 |
|---|---|---|---|---|
|
UniProtKB:Q5EFQ8
|
180 |
Interactions and Pathways
Plasmids
No data available