FIGURE

Figure 5

ID

ZDB-FIG-221020-62

Publication

Xu et al., 2022 - Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging

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Figure 5

Apoptosis and cell cycle arrest in zebrafish larvae caused by Cd²⁺ are mediated by Wnt signaling pathway. (A,B) Flow cytometry analysis and distribution of cell cycle phase of neurons and neuronal precursor cells. (C,D) Vertical view in the brain of AO-stained zebrafish larvae (6 dpf) and statistics of apoptotic cell numbers. (E) Relative expression analysis of genes related to cell apoptosis. In histograms, values are represented as mean ± SEM, while in boxplots, values are represented as median and mean, and whiskers signify 90% confidence interval. The results of nonparametric test and ANOVA, as well as multiple comparison test are listed in Table S2. “*” indicates significant differences (* p < 0.05, ** p < 0.01, *** p < 0.001).

Expression Data

Genes:	baxa bcl2a casp3a casp8 tp53
Fish:	knu3Tg/knu3Tg
Conditions:	chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride
Anatomical Term:	whole organism
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	knu3Tg/knu3Tg
Conditions:	chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride
Observed In:	neuron apoptotic process neuron regulation of cell cycle whole organism
Stage:	Day 6

Phenotype Detail

Acknowledgments

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