Gene
casp3a
- ID
- ZDB-GENE-011210-1
- Name
- caspase 3, apoptosis-related cysteine peptidase a
- Symbol
- casp3a Nomenclature History
- Previous Names
-
- casp3
- zgc:100890
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables peptidase activity. Acts upstream of or within several processes, including cellular response to antibiotic; cellular response to retinoic acid; and regulation of collateral sprouting in absence of injury. Predicted to be part of death-inducing signaling complex. Predicted to be active in cytoplasm. Is expressed in several structures, including axis; gonad; gut; nervous system; and pericardial region. Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach cancer. Orthologous to human CASP3 (caspase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 70 figures from 54 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu109 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zko331a | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-casp3a | (2) | |
| CRISPR2-casp3a | Wang et al., 2020 | |
| CRISPR3-casp3a | (2) | |
| CRISPR4-casp3a | (2) | |
| CRISPR5-casp3a | Wang et al., 2020 | |
| CRISPR6-casp3a | Zhang et al., 2021 | |
| CRISPR8-casp3a | Zhang et al., 2021 | |
| MO1-casp3a | N/A | (5) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016129 | Peptidase family C14A, His active site |
| Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
| Domain | IPR011600 | Peptidase C14, caspase domain |
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Domain Details Per Protein
| Protein | Length | Caspase-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site | Peptidase family C14A, His active site |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QUC0
|
282 | |||||||
|
UniProtKB:Q98UI8
|
282 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
casp3a-201
(1)
|
Ensembl | 2,918 nt | ||
| mRNA |
casp3a-202
(1)
|
Ensembl | 862 nt | ||
| mRNA |
casp3a-203
(1)
|
Ensembl | 792 nt | ||
| mRNA |
casp3a-204
(1)
|
Ensembl | 471 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(5xUAS:casp3a,5xUAS:Hsa.HIST1H2BJ-Citrine,cryaa:RFP) |
| 1 | (3) | ||
| Tg(CMV:casp3a,CMV:GFP) |
|
| 2 | (3) | |
| Tg(UAS:casp3a-UTRnanos3,CMV:EGFP) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-197N1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-228C11 | ZFIN Curated Data | |
| Encodes | EST | eu109 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:100890 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131877 (1) | 2946 nt | ||
| Genomic | GenBank:BX537280 (2) | 163151 nt | ||
| Polypeptide | UniProtKB:A0A2R8QUC0 (1) | 282 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Gawel, K., Hulas-Stasiak, M., Marszalek-Grabska, M., Grenda, A., Siekierska, A., Kosheva, N., van der Ent, W., Esguerra, C.V., Krawczyk, P., Turski, W.A. (2024) Induction of seizures and initiation of epileptogenesis by pilocarpine in zebrafish larvae. Frontiers in molecular neuroscience. 17:14186061418606
- Jiang, Z., Deng, L., Xiang, G., Xu, X., Wang, Y. (2024) A Mechanistic Study of the Osteogenic Effect of Arecoline in an Osteoporosis Model: Inhibition of Iron Overload-Induced Osteogenesis by Promoting Heme Oxygenase-1 Expression. Antioxidants (Basel, Switzerland). 13(4):
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
- Zhang, Z., Zhang, H.L., Yang, D.H., Hao, Q., Yang, H.W., Meng, D.L., Meindert de Vos, W., Guan, L.L., Liu, S.B., Teame, T., Gao, C.C., Ran, C., Yang, Y.L., Yao, Y.Y., Ding, Q.W., Zhou, Z.G. (2024) Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects. iMeta. 3:e181e181
- Zhao, S., Mo, G., Wang, Q., Xu, J., Yu, S., Huang, Z., Liu, W., Zhang, W. (2024) Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b. Cell death discovery. 10:182182
- Azbazdar, Y., Poyraz, Y.K., Ozalp, O., Nazli, D., Ipekgil, D., Cucun, G., Ozhan, G. (2023) High-fat diet feeding triggers a regenerative response in the adult zebrafish brain. Molecular neurobiology. 60(5):2486-2506
- Chen, J., Ren, C., Yao, C., Baruscotti, M., Wang, Y., Zhao, L. (2023) Identification of the natural chalcone glycoside hydroxysafflor yellow A as a suppressor of P53 overactivation-associated hematopoietic defects. MedComm. 4:e352e352
- Ding, C., Du, M., Xiong, Z., Wang, X., Li, H., He, E., Li, H., Dang, Y., Lu, Q., Li, S., Xiao, R., Xu, Z., Jing, L., Deng, L., Wang, X., Geng, M., Xie, Z., Zhang, A. (2023) Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth. Chemical science. 14:595659645956-5964
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