Gene

casp3a

ID
ZDB-GENE-011210-1
Name
caspase 3, apoptosis-related cysteine peptidase a
Symbol
casp3a Nomenclature History
Previous Names
  • casp3
  • zgc:100890
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Exhibits peptidase activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of apoptotic process; and regulation of collateral sprouting in absence of injury. Predicted to localize to cytoplasm. Is expressed in several structures, including axis; germ ring; gonad; gut; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP3 (caspase 3).
Genome Resources
Note
None
Expression
All Expression Data
35 figures from 24 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With casp3a Human Ortholog
No data available
Associated With casp3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016129 Peptidase family C14A, His active site
Active_site IPR033139 Peptidase family C14A, cysteine active site
Domain IPR001309 Peptidase C14, p20 domain
Domain IPR002138 Peptidase C14, caspase non-catalytic subunit p10
Domain IPR015917 Peptidase C14A, caspase catalytic domain
Family IPR002398 Peptidase C14 family
Family IPR015471 Caspase-7
Homologous_superfamily IPR029030 Caspase-like domain superfamily
Domain Details Per Protein
Protein Length Caspase-7 Caspase-like domain superfamily Peptidase C14A, caspase catalytic domain Peptidase C14, caspase non-catalytic subunit p10 Peptidase C14 family Peptidase C14, p20 domain Peptidase family C14A, cysteine active site Peptidase family C14A, His active site
UniProtKB:B8JK21 282
UniProtKB:E9QIX2 120
UniProtKB:Q98UI8 282
UniProtKB:A0A1C9CJ76 282
UniProtKB:F1QDH1 206
UniProtKB:B8JK20 151
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations