FIGURE

Figure 4

ID

ZDB-FIG-221020-59

Publication

Xu et al., 2022 - Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging

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Figure 4

Involvement of zebrafish Wnt signaling pathway in Cd²⁺-induced neurodevelopmental disorders. (A,B) Fluorescence imaging of 6 dpf Tg(elavl3:EGFP) larvae and statistics of relative fluorescence intensity. (C,D) Confocal fluorescence imaging of the telencephalon and midbrain regions, as well as the statistics of telencephalon proportion. (E,F) Imaging of the PVL region in 6 dpf Tg(elavl3: EGFP) larvae and density statistics of PVN. (G–I) Imaging of trigeminal ganglion neurons and structural analysis in 24 hpf zebrafish embryos. (J) Relative expression of genes related to neurodevelopment and differentiation. In histograms, values are represented as mean ± SEM, while in boxplots, values are represented as median and mean, and whiskers show 90% confidence levels. The results of nonparametric test and ANOVA, as well as multiple comparison test are listed in Table S2. “*” indicates significant differences (* p < 0.05, ** p < 0.01, *** p < 0.001).

Expression Data

Genes:	EGFP elavl3 gap43 nes syn2a tuba1b
Fish:	knu3Tg/knu3Tg
Conditions:	chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride
Anatomical Terms:	nervous system optic tectum telencephalon trigeminal ganglion whole organism
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	knu3Tg/knu3Tg
Conditions:	chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride
Observed In:	nervous system optic tectum telencephalon trigeminal ganglion trigeminal ganglion branching morphogenesis of a nerve whole organism
Stage:	Day 6

Phenotype Detail

Acknowledgments

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