Gene

bcl2a

ID

ZDB-GENE-051012-1

Name

BCL2 apoptosis regulator a

Symbol

bcl2a Nomenclature History

Previous Names

bcl2
zBlp2 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Enables protein heterodimerization activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including anterior lateral mesoderm; corpuscles of Stannius; digestive system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

49 figures from 43 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bcl2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Leukemia/lymphoma, B-cell, 2

Associated With bcl2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site
Conserved_site	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site
Domain	IPR003093	Apoptosis regulator, Bcl-2 protein, BH4
Domain	IPR046371	Bcl-2, Bcl-2 homology region 1-3
Family	IPR002475	Bcl2-like
Family	IPR013279	Apoptosis regulator, Bcl-X
Family	IPR026298	Bcl-2 family
Homologous_superfamily	IPR036834	Bcl-2-like superfamily