Gene

bcl2a

ID

ZDB-GENE-051012-1

Name

BCL2 apoptosis regulator a

Symbol

bcl2a Nomenclature History

Previous Names

bcl2
zBlp2 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Exhibits protein heterodimerization activity. Involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to mitochondrial outer membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Is expressed in several structures, including anterior lateral mesoderm; corpuscles of Stannius; immature B cell; nervous system; and pleuroperitoneal region. Orthologous to human BCL2 (BCL2 apoptosis regulator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

40 figures from 38 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bcl2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Leukemia/lymphoma, B-cell, 2

Associated With bcl2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site
Conserved_site	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site
Domain	IPR003093	Apoptosis regulator, Bcl-2 protein, BH4
Domain	IPR046371	Bcl-2, Bcl-2 homology region 1-3
Family	IPR002475	Bcl2-like
Family	IPR013279	Apoptosis regulator, Bcl-X
Family	IPR026298	Bcl-2 family
Homologous_superfamily	IPR036834	Bcl-2-like superfamily