Gene

bcl2a

ID
ZDB-GENE-051012-1
Name
BCL2 apoptosis regulator a
Symbol
bcl2a Nomenclature History
Previous Names
  • bcl2
  • zBlp2 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Exhibits protein heterodimerization activity. Involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to mitochondrial outer membrane. Is expressed in several structures, including anterior lateral mesoderm; corpuscles of Stannius; immature B cell; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).
Genome Resources
Note
None
Expression
All Expression Data
23 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bcl2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leukemia/lymphoma, B-cell, 2
Associated With bcl2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
Conserved_site IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
Domain IPR003093 Apoptosis regulator, Bcl-2 protein, BH4
Family IPR002475 Bcl2-like
Family IPR013278 Apoptosis regulator, Bcl-2
Family IPR013279 Apoptosis regulator, Bcl-X
Family IPR026298 Blc2 family
Homologous_superfamily IPR036834 Blc2-like superfamily
Domain Details Per Protein
Protein Length Apoptosis regulator, Bcl-2 Apoptosis regulator, Bcl-2, BH1 motif, conserved site Apoptosis regulator, Bcl-2, BH2 motif, conserved site Apoptosis regulator, Bcl-2 protein, BH4 Apoptosis regulator, Bcl-X Bcl2-like Blc2 family Blc2-like superfamily
UniProtKB:Q564A4 228
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations