Gene

bcl2a

ID
ZDB-GENE-051012-1
Name
BCL2 apoptosis regulator a
Symbol
bcl2a Nomenclature History
Previous Names
  • bcl2
  • zBlp2 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Enables protein heterodimerization activity. Acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in endoplasmic reticulum membrane; mitochondrion; and nuclear membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including anterior lateral mesoderm; corpuscles of Stannius; immature B cell; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
24 figures from 24 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bcl2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leukemia/lymphoma, B-cell, 2
Associated With bcl2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
Conserved_site IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
Domain IPR003093 Apoptosis regulator, Bcl-2 protein, BH4
Family IPR002475 Bcl2-like
Family IPR013278 Apoptosis regulator, Bcl-2
Family IPR013279 Apoptosis regulator, Bcl-X
Family IPR026298 Blc2 family
Homologous_superfamily IPR036834 Blc2-like superfamily
Domain Details Per Protein
Protein Length Apoptosis regulator, Bcl-2 Apoptosis regulator, Bcl-2, BH1 motif, conserved site Apoptosis regulator, Bcl-2, BH2 motif, conserved site Apoptosis regulator, Bcl-2 protein, BH4 Apoptosis regulator, Bcl-X Bcl2-like Blc2 family Blc2-like superfamily
UniProtKB:Q564A4 228
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations