Gene
bcl2a
- ID
- ZDB-GENE-051012-1
- Name
- BCL2 apoptosis regulator a
- Symbol
- bcl2a Nomenclature History
- Previous Names
-
- bcl2
- zBlp2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Exhibits protein heterodimerization activity. Involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to mitochondrial outer membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Is expressed in several structures, including anterior lateral mesoderm; corpuscles of Stannius; immature B cell; nervous system; and pleuroperitoneal region. Orthologous to human BCL2 (BCL2 apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 47 figures from 41 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Leukemia/lymphoma, B-cell, 2 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR020717 | Apoptosis regulator, Bcl-2, BH1 motif, conserved site |
Conserved_site | IPR020726 | Apoptosis regulator, Bcl-2, BH2 motif, conserved site |
Domain | IPR003093 | Apoptosis regulator, Bcl-2 protein, BH4 |
Domain | IPR046371 | Bcl-2, Bcl-2 homology region 1-3 |
Family | IPR002475 | Bcl2-like |
Family | IPR013279 | Apoptosis regulator, Bcl-X |
Family | IPR026298 | Bcl-2 family |
Homologous_superfamily | IPR036834 | Bcl-2-like superfamily |
Domain Details Per Protein
Protein | Length | Apoptosis regulator, Bcl-2, BH1 motif, conserved site | Apoptosis regulator, Bcl-2, BH2 motif, conserved site | Apoptosis regulator, Bcl-2 protein, BH4 | Apoptosis regulator, Bcl-X | Bcl-2, Bcl-2 homology region 1-3 | Bcl-2 family | Bcl2-like | Bcl-2-like superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q564A4
|
228 |
Interactions and Pathways
No data available
Plasmids
No data available