Gene
bcl2a
- ID
- ZDB-GENE-051012-1
- Name
- BCL2 apoptosis regulator a
- Symbol
- bcl2a Nomenclature History
- Previous Names
-
- bcl2
- zBlp2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including anterior lateral mesoderm; corpuscles of Stannius; digestive system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 51 figures from 45 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-bcl2a | N/A | Kratz et al., 2006 |
| MO2-bcl2a | N/A | O'Hare et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leukemia/lymphoma, B-cell, 2 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020717 | Apoptosis regulator, Bcl-2, BH1 motif, conserved site |
| Conserved_site | IPR020726 | Apoptosis regulator, Bcl-2, BH2 motif, conserved site |
| Domain | IPR003093 | Apoptosis regulator, Bcl-2 protein, BH4 |
| Domain | IPR046371 | Bcl-2, Bcl-2 homology region 1-3 |
| Family | IPR002475 | Bcl2-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Apoptosis regulator, Bcl-2, BH1 motif, conserved site | Apoptosis regulator, Bcl-2, BH2 motif, conserved site | Apoptosis regulator, Bcl-2 protein, BH4 | Apoptosis regulator, Bcl-X | Bcl-2, Bcl-2 homology region 1-3 | Bcl-2 family | Bcl2-like | Bcl-2-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q564A4 | InterPro | 228 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Gt2(bcl2a-EGFP) |
|
| 3 | (9) | |
| Gt(bcl2a-EGFP) |
|
| 5 | (17) | |
| Tg(hsp70l:bcl2a-2A-CAAX-EGFP) |
| 1 | Atieh et al., 2020 | ||
| Tg(hsp70l:mCherry-bcl2a) |
|
| 1 | (3) | |
| Tg(hsp70l:mCherry-bcl2a-ERLS) |
| 1 | Nishiwaki et al., 2020 | ||
| Tg(myo6b:EGFP-bcl2a,myl7:EGFP) |
|
| 1 | (3) | |
| Tg(rag2:EGFP-bcl2a) |
|
| 1 | (12) | |
| Tg(rag2:mCherry-bcl2a) |
|
| 1 | Harrold et al., 2016 | |
| Tg(Xla.Tubb2b:bcl2a) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-74B21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-121F17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162054 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030253 (1) | 1150 nt | ||
| Genomic | GenBank:CU695001 (1) | 93715 nt | ||
| Polypeptide | UniProtKB:Q564A4 (1) | 228 aa |
- Belt, A.J., Grant, S., Tombes, R.M., Rothschild, S.C. (2024) Myeloid Targeted Human MLL-ENL and MLL-AF9 Induces cdk9 and bcl2 Expression in Zebrafish Embryos. PLoS Genetics. 20:e1011308e1011308
- Chiang, H.J., Nishiwaki, Y., Chiang, W.C., Masai, I. (2024) Male germ cell-associated kinase (MAK) is required for axoneme formation during ciliogenesis in zebrafish photoreceptors. Disease models & mechanisms. 17(7):
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Li, K., Fan, D., Zhou, J., Zhao, Z., Han, A., Song, Z., Tang, X., Hu, B. (2024) Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43. International Journal of Molecular Sciences. 25(20):
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
- Ranasinghe, T., Seo, Y., Park, H.C., Choe, S.K., Cha, S.H. (2024) Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo. Journal of hazardous materials. 480:136215136215
- Rayamajhi, D., Ege, M., Ukhanov, K., Ringers, C., Zhang, Y., Jung, I., D'Gama, P.P., Li, S.S., Cosacak, M.I., Kizil, C., Park, H.C., Yaksi, E., Martens, J.R., Brody, S.L., Jurisch-Yaksi, N., Roy, S. (2024) The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. PLoS Biology. 22:e3002468e3002468
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Wijerathna, H.M.S.M., Shanaka, K.A.S.N., Raguvaran, S.S., Jayamali, B.P.M.V., Kim, S.H., Kim, M.J., Jung, S., Lee, J. (2024) CRISPR/Cas9-Mediated fech Knockout Zebrafish: Unraveling the Pathogenesis of Erythropoietic Protoporphyria and Facilitating Drug Screening. International Journal of Molecular Sciences. 25(19):
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