Gene

casp8

ID
ZDB-GENE-000713-1
Name
caspase 8, apoptosis-related cysteine peptidase
Symbol
casp8 Nomenclature History
Previous Names
  • caspase-8a (1)
  • zgc:92075
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Is predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; and death effector domain binding activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and apoptotic process. Acts upstream of or within induction by virus of host apoptotic process and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Is expressed in several structures, including axis; germ ring; heart; intestinal bulb; and nervous system. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and primary immunodeficiency disease. Orthologous to human CASP8 (caspase 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
23 figures from 21 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With casp8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autoimmune lymphoproliferative syndrome type 2B Alliance ?Autoimmune lymphoproliferative syndrome, type IIB 607271
breast cancer Alliance {Breast cancer, protection against} 114480
hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
lung cancer Alliance {Lung cancer, protection against} 211980
Associated With casp8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR033139 Peptidase family C14A, cysteine active site
Domain IPR001309 Peptidase C14, p20 domain
Domain IPR001875 Death effector domain
Domain IPR002138 Peptidase C14, caspase non-catalytic subunit p10
Domain IPR015917 Peptidase C14A, caspase catalytic domain
Family IPR002398 Peptidase C14 family
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR029030 Caspase-like domain superfamily
Domain Details Per Protein
Protein Length Caspase-like domain superfamily Death effector domain Death-like domain superfamily Peptidase C14A, caspase catalytic domain Peptidase C14, caspase non-catalytic subunit p10 Peptidase C14 family Peptidase C14, p20 domain Peptidase family C14A, cysteine active site
UniProtKB:A0A2U9DQK9 477
UniProtKB:Q56VC8 476
UniProtKB:Q9I8J3 476
UniProtKB:F1QLH0 476
UniProtKB:Q66I19 476
UniProtKB:Q56VC7 397
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-casp8 polyclonal Rabbit
  • IHC
AnaSpec
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations