FIGURE

Figure 6

ID

ZDB-FIG-221020-64

Publication

Xu et al., 2022 - Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging

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Figure 6

Role of zebrafish Wnt signaling pathway in Cd²⁺-induced microgliosis and neuroinflammation. (A–D) Morphological alterations of microglia in 6 dpf Tg(ApoE-EGFP) zebrafish larvae, and quantification of morphological parameters. (E,F) In vivo neuroimaging and microglia counting in the optic tectum region of 6 dpf zebrafish larvae. (G) Expression patterns of genes closely related with microgliosis and neuroinflammatory response. The numerical values are presented as either mean ± SEM in histograms, or median and mean, while whiskers show 90% confidence levels in boxplots. The results of either nonparametric test or ANOVA followed by multiple comparison test are listed in Table S2. “*” indicates significant differences (* p < 0.05, ** p < 0.01, *** p < 0.001).

Expression Data

Genes:	apoeb irf8 tnfa
Fish:	AB
Conditions:	chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride
Anatomical Term:	whole organism
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf147Tg/zf147Tg AB
Conditions:	chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride chemical treatment by environment: cadmium dichloride
Observed In:	microglial cell optic tectum microglial cell whole organism
Stage:	Day 6

Phenotype Detail

Acknowledgments

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