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Figure 5

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Xu et al., 2022 - Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging

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Figure 5

Apoptosis and cell cycle arrest in zebrafish larvae caused by Cd²⁺ are mediated by Wnt signaling pathway. (A,B) Flow cytometry analysis and distribution of cell cycle phase of neurons and neuronal precursor cells. (C,D) Vertical view in the brain of AO-stained zebrafish larvae (6 dpf) and statistics of apoptotic cell numbers. (E) Relative expression analysis of genes related to cell apoptosis. In histograms, values are represented as mean ± SEM, while in boxplots, values are represented as median and mean, and whiskers signify 90% confidence interval. The results of nonparametric test and ANOVA, as well as multiple comparison test are listed in Table S2. “*” indicates significant differences (* p < 0.05, ** p < 0.01, *** p < 0.001).

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.