ZFIN ID: ZDB-GENE-990415-270
Gene Name: tumor protein p53
Gene Symbol: tp53
Sequence Ontology ID : SO:0000704

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Previous Names: p53 (1), brp53, drp53, etID22686.5 (1), fb40d06, wu:fb40d06 (1), zgc:111919

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(Including Attributions)
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits DNA-binding activity transcription factor activity and sequence-specific DNA binding activity; involved in several processes, including hemopoiesis, intracellular signal transduction, and  ...
GENE EXPRESSION
All Expression Data: 142 figures from 110 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:111919]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hg91 Small Deletion Exon 5 Frameshift CRISPR
hsi6 Complex Unknown Unknown CRISPR
hsi7 Complex Unknown Unknown CRISPR
hu888 Point Mutation Acceptor Splice Site of Intron 8 Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ihb135 Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • ihb136 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • la015599Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024884Tg Transgenic Insertion Unknown Unknown DNA
    la024885Tg Transgenic Insertion Unknown Unknown DNA
    la024886Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029070Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1114 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20404 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20405 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zdf1 Point Mutation Exon 7 Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zdf2 Point Mutation Exon 6 Missense ENU
    zdf3 Point Mutation Exon 4 Missense ENU
    zdf4 Point Mutation Exon 5 Missense ENU
    zdf5 Point Mutation Unknown Unknown ENU
    zju101 Small Deletion Promoter Unknown TALEN
    zy7 Point Mutation Unknown Unknown ENU
    Targeting reagents:
    PHENOTYPE
    Data: 23 figures from 20 publications
    Observed in:
    DISEASE ASSOCIATED WITH tp53 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    adrenocortical carcinoma {Adrenocortical carcinoma, pediatric} 202300
    breast cancer Breast cancer, somatic 114480
    choroid plexus papilloma {Choroid plexus papilloma} 260500
    colorectal cancer {Colorectal cancer} 114500
    hepatocellular carcinoma Hepatocellular carcinoma, somatic 114550
    Li-Fraumeni syndrome Li-Fraumeni syndrome 151623
    nasopharynx carcinoma Nasopharyngeal carcinoma, somatic 607107
    osteosarcoma {Osteosarcoma} 259500
    pancreatic carcinoma Pancreatic cancer, somatic 260350
    Bone marrow failure syndrome 5 618165
    {Glioma susceptibility 1} 137800
    {Basal cell carcinoma 7} 614740
    DISEASE ASSOCIATED WITH tp53 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Li-Fraumeni syndrome tp53zy7/+(AB) standard conditions Parant et al., 2010
    tp53zy7/zy7(AB) standard conditions Parant et al., 2010
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component chromatin (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 60)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002117 (1)
  • InterPro:IPR008967 (1)
  • InterPro:IPR010991 (1)
  • InterPro:IPR011615 (1)
  • InterPro:IPR012346 (1)
  • InterPro:IPR036674 (1)
  • PROSITE:PS00348 (1)
  • Pfam:PF00870 (1)
  • Pfam:PF07710 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA tp53-002 (1) 802
    tp53-003 (1) 579
    tp53-004 (1) 748
    mRNA tp53-203 (1) 2204
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM tp53
    MARKER RELATIONSHIPS
    tp53Contained in: [BAC] CH211-114C12 (1) (order this)
    tp53Encodes: [EST] fb40d06 (1)
    [cDNA] MGC:111919 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131327 (1) 2105bp
    Genomic GenBank:AL928875 (1) 158038bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8RHX5 (1) 374aa
    Sequence Clusters UniGene:75100 (1)
    Sequence Information (all 54)
    OTHER tp53 GENE PAGES
  • Alliance (1)
  • Gene:30590 (1)
  • VEGA:OTTDARG00000016232 (1)
  • ORTHOLOGY for tp53 (Chr: 5)
    CITATIONS (1115)