ZFIN ID: ZDB-GENE-990415-270
Gene Name: tumor protein p53
Gene Symbol: tp53    Nomenclature History

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Previous Names: p53 (1), brp53, drp53, etID22686.5 (1), fb40d06, wu:fb40d06 (1), zgc:111919

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of apoptotic process; regulation of nucleobase-containing compound metabolic process; and signal transduction by p53 class mediator. Localizes to chromatin. Is expressed in several structures, including digestive system; head; musculature system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; and cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).
Genome Resources: Alliance (1),  Gene:30590 (1),  Ensembl(GRCz11):ENSDARG00000035559 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fb105 Indel Unknown Unknown TALEN
hg91 Small Deletion Exon 5 Frameshift CRISPR
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hsi6 Complex Unknown Unknown CRISPR
    hsi7 Complex Unknown Unknown CRISPR
    hu888 Point Mutation Acceptor Splice Site of Intron 8 Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ihb135 Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb136 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ka801 Small Deletion Unknown Unknown CRISPR
    la015599Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024884Tg Transgenic Insertion Unknown Unknown DNA
    la024885Tg Transgenic Insertion Unknown Unknown DNA
    la024886Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029070Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1114 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20404 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20405 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zdf1 Point Mutation Exon 7 Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zdf2 Point Mutation Exon 6 Missense ENU
    zdf3 Point Mutation Exon 4 Missense ENU
    zdf4 Point Mutation Exon 5 Missense ENU
    zdf5 Point Mutation Unknown Unknown ENU
    umo16 Insertion Unknown Unknown TALEN
    zju101 Small Deletion Promoter Unknown TALEN
    zy7 Point Mutation Unknown Missense ENU
    DISEASE ASSOCIATED WITH tp53 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    adrenocortical carcinoma Alliance {Adrenocortical carcinoma, pediatric} 202300
    breast cancer Alliance Breast cancer, somatic 114480
    choroid plexus papilloma Alliance {Choroid plexus papilloma} 260500
    colorectal cancer Alliance {Colorectal cancer} 114500
    hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
    Li-Fraumeni syndrome 1 Alliance Li-Fraumeni syndrome 151623
    nasopharynx carcinoma Alliance Nasopharyngeal carcinoma, somatic 607107
    osteosarcoma Alliance {Osteosarcoma} 259500
    pancreatic carcinoma Alliance Pancreatic cancer, somatic 260350
    Bone marrow failure syndrome 5 618165
    {Basal cell carcinoma 7} 614740
    {Glioma susceptibility 1} 137800
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component chromatin (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 45)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tp53-203 (1)    Ensembl 2204
    ncRNA tp53-002 (1)    Ensembl 802
    tp53-003 (1)    Ensembl 579
    tp53-004 (1)    Ensembl 748
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tp53 monoclonal Mouse IHC, WB 3
    Ab10-tp53 monoclonal Mouse IHC, WB 7
    Ab11-tp53 monoclonal IgG Mouse WB Abcam plc
    9
    Ab2-tp53 monoclonal IgG1 Mouse IHC, WB 3
    Ab6-tp53 monoclonal Mouse WB 2
    Ab7-tp53 polyclonal Rabbit WB AnaSpec
    5
    Ab3-tp53 monoclonal IgG1 Mouse WB 6
    Ab4-tp53 polyclonal Rabbit 1
    Ab9-tp53 polyclonal Rabbit 1
    CONSTRUCTS WITH SEQUENCES FROM tp53
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(tp53-002:GFP) tp53tp53-002 GFP Danio rerio 1 4
    Tg(tp53:EGFP) tp53 EGFP Danio rerio 0 1
    MARKER RELATIONSHIPS
    tp53 Contained in: [BAC] CH211-114C12 (1)
    tp53 Encodes: [EST] fb40d06 (1)
    [cDNA] MGC:111919 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131327 (1) 2105 nt
    Genomic GenBank:AL928875 (1) 158038 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8RHX5 (1) 374 aa
    Sequence Information (all 53)
    ORTHOLOGY for tp53 ( Chr: 5 )
    CITATIONS (1242)