Gene

tp53

ID
ZDB-GENE-990415-270
Name
tumor protein p53
Symbol
tp53 Nomenclature History
Previous Names
  • p53 (1)
  • brp53
  • drp53
  • etID22686.5 (1)
  • fb40d06
  • wu:fb40d06 (1)
  • zgc:111919
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of apoptotic process; regulation of nucleobase-containing compound metabolic process; and signal transduction by p53 class mediator. Localizes to chromatin. Is expressed in several structures, including digestive system; head; musculature system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; and cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).
Genome Resources
Note
None
Expression
All Expression Data
159 figures from 127 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
36 figures from 29 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tp53 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
adrenocortical carcinoma Alliance {Adrenocortical carcinoma, pediatric} 202300
breast cancer Alliance Breast cancer, somatic 114480
choroid plexus papilloma Alliance {Choroid plexus papilloma} 260500
colorectal cancer Alliance {Colorectal cancer} 114500
hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
Li-Fraumeni syndrome 1 Alliance Li-Fraumeni syndrome 151623
nasopharynx carcinoma Alliance Nasopharyngeal carcinoma, somatic 607107
osteosarcoma Alliance {Osteosarcoma} 259500
pancreatic carcinoma Alliance Pancreatic cancer, somatic 260350
Bone marrow failure syndrome 5 618165
{Basal cell carcinoma 7} 614740
{Glioma susceptibility 1} 137800
Associated With tp53 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR010991 p53, tetramerisation domain
Domain IPR011615 p53, DNA-binding domain
Family IPR002117 p53 tumour suppressor family
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR036674 p53-like tetramerisation domain superfamily
Domain Details Per Protein
Protein Length p53, DNA-binding domain p53-like tetramerisation domain superfamily p53-like transcription factor, DNA-binding p53/RUNT-type transcription factor, DNA-binding domain superfamily p53, tetramerisation domain p53 tumour suppressor family
UniProtKB:G1K2L5 374
UniProtKB:Q502Q9 374
UniProtKB:B0R0M3 369
UniProtKB:A0A0B4VEV8 294
UniProtKB:P79734 373
UniProtKB:A0A0B4VFS7 261
UniProtKB:A0A2R8RTB8 294
UniProtKB:A0A0B4VEY6 289
UniProtKB:A0A2R8RHX5 374
UniProtKB:A0A2R8Q2E9 289
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tp53 monoclonal Mouse
  • IHC
  • WB
3
Ab10-tp53 monoclonal Mouse
  • IHC
  • WB
8
Ab11-tp53 monoclonal IgG Mouse
  • WB
Abcam plc
10
Ab2-tp53 monoclonal IgG1 Mouse
  • IHC
  • WB
3
Ab6-tp53 monoclonal Mouse
  • WB
2
Ab7-tp53 polyclonal Rabbit
  • WB
AnaSpec
5
Ab3-tp53 monoclonal IgG1 Mouse
  • WB
6
Ab4-tp53 polyclonal Rabbit
1
Ab9-tp53 polyclonal Rabbit
1
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations