Gene
baxa
- ID
- ZDB-GENE-000511-6
- Name
- BCL2 associated X, apoptosis regulator a
- Symbol
- baxa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable channel activity; protein heterodimerization activity; and protein homodimerization activity. Acts upstream of or within several processes, including positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to cadmium ion; and response to methylmercury. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including digestive system; female organism; heart; immune system; and male organism. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Orthologous to human BAX (BCL2 associated X, apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 51 figures from 45 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66309 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute lymphoblastic leukemia | Alliance | T-cell acute lymphoblastic leukemia, somatic | 613065 |
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Apoptosis regulator BAX | Bcl2-like | Blc2 family | Blc2-like superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q9I9N4
|
192 | ||||
|
UniProtKB:E7F9W2
|
115 | ||||
|
UniProtKB:I3ITC2
|
197 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance