Gene
baxa
- ID
- ZDB-GENE-000511-6
- Name
- BCL2 associated X, apoptosis regulator a
- Symbol
- baxa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have channel activity; protein heterodimerization activity; and protein homodimerization activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to cadmium ion; and response to methylmercury. Predicted to localize to mitochondrial outer membrane. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Is expressed in several structures, including digestive system; female organism; heart; immune system; and male organism. Orthologous to human BAX (BCL2 associated X, apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 56 figures from 50 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66309 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute lymphoblastic leukemia | Alliance | T-cell acute lymphoblastic leukemia, somatic | 613065 |
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Apoptosis regulator BAX | Bcl-2 family | Bcl2-like | Bcl-2-like superfamily |
|---|---|---|---|---|---|
|
UniProtKB:E7F9W2
|
115 | ||||
|
UniProtKB:I3ITC2
|
197 | ||||
|
UniProtKB:Q9I9N4
|
192 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance