Gene

baxa

ID
ZDB-GENE-000511-6
Name
BCL2 associated X, apoptosis regulator a
Symbol
baxa Nomenclature History
Previous Names
  • bax
  • fj16e01
  • wu:fc50b10
  • wu:fj16e01 (1)
  • zBax1 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have channel activity; protein heterodimerization activity; and protein homodimerization activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to cadmium ion; and response to methylmercury. Predicted to localize to mitochondrial outer membrane. Is expressed in several structures, including digestive system; female organism; heart; immune system; and male organism. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Orthologous to human BAX (BCL2 associated X, apoptosis regulator).
Genome Resources
Note
None
Expression
All Expression Data
43 figures from 38 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With baxa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphoblastic leukemia Alliance T-cell acute lymphoblastic leukemia, somatic 613065
colorectal cancer Alliance Colorectal cancer, somatic 114500
Associated With baxa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002475 Bcl2-like
Family IPR026298 Blc2 family
Homologous_superfamily IPR036834 Blc2-like superfamily
Domain Details Per Protein
Protein Length Bcl2-like Blc2 family Blc2-like superfamily
UniProtKB:I3ITC2 197
UniProtKB:E7F9W2 115
UniProtKB:Q9I9N4 192
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Citations