Gene
baxa
- ID
- ZDB-GENE-000511-6
- Name
- BCL2 associated X, apoptosis regulator a
- Symbol
- baxa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable channel activity. Acts upstream of or within positive regulation of apoptotic process; response to cadmium ion; and response to methylmercury. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including digestive system; female organism; immune system; male organism; and musculature system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Orthologous to human BAX (BCL2 associated X, apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 78 figures from 70 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66309 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cq55 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa6041 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14515 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf3221 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zf3986 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zf3987 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-baxa | Zhao et al., 2022 | |
| CRISPR2-baxa | Zhao et al., 2022 | |
| MO1-baxa | N/A | Arnaud et al., 2006 |
| MO2-baxa | N/A | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute lymphoblastic leukemia | Alliance | T-cell acute lymphoblastic leukemia, somatic | 613065 |
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Bcl-2, Bcl-2 homology region 1-3 | Bcl-2 family | Bcl2-like | Bcl-2-like superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q9I9N4 | InterPro | 192 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-260C8 | ZFIN Curated Data | |
| Encodes | EST | fc50b10 | ||
| Encodes | EST | fj16e01 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66309 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192165 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131562 (1) | 1960 nt | ||
| Genomic | GenBank:CR388062 (2) | 153088 nt | ||
| Polypeptide | UniProtKB:Q9I9N4 (1) | 192 aa |
- Comparative Orthology
- Alliance
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Han, X., He, W., Liang, D., Liu, X., Zhou, J., de Thé, H., Zhu, J., Yuan, H. (2024) Creg1 Regulates Erythroid Development via TGF-β/Smad2-Klf1 Axis in Zebrafish. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(33):e2402804
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Wijerathna, H.M.S.M., Shanaka, K.A.S.N., Raguvaran, S.S., Jayamali, B.P.M.V., Kim, S.H., Kim, M.J., Jung, S., Lee, J. (2024) CRISPR/Cas9-Mediated fech Knockout Zebrafish: Unraveling the Pathogenesis of Erythropoietic Protoporphyria and Facilitating Drug Screening. International Journal of Molecular Sciences. 25(19):
- Xu, W., Liu, X., Li, J., Sun, C., Chen, L., Zhou, J., Li, K., Li, Q., Meng, A., Sun, Q. (2024) ULI-ssDRIP-seq revealed R-loop dynamics during vertebrate early embryogenesis. Cell insight. 3:100179100179
- Aranda-Martínez, P., Fernández-Martínez, J., Ramírez-Casas, Y., Rodríguez-Santana, C., Rusanova, I., Escames, G., Acuña-Castroviejo, D. (2023) Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment. Antioxidants (Basel, Switzerland). 12(4):
- Chen, J., Baxi, K., Lipsitt, A.E., Hensch, N.R., Wang, L., Sreenivas, P., Modi, P., Zhao, X.R., Baudin, A., Robledo, D.G., Bandyopadhyay, A., Sugalski, A., Challa, A.K., Kurmashev, D., Gilbert, A.R., Tomlinson, G.E., Houghton, P., Chen, Y., Hayes, M.N., Chen, E.Y., Libich, D.S., Ignatius, M.S. (2023) Defining function of wild-type and three patient specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma. eLIFE. 12:
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