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ZIRC
ZFIN ID: ZDB-GENE-000511-6
Gene Name: BCL2 associated X, apoptosis regulator a
Gene Symbol: baxa    Nomenclature History

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Previous Names: bax, fj16e01, wu:fc50b10, wu:fj16e01 (1), zBax1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have channel activity; protein heterodimerization activity; and protein homodimerization activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to cadmium ion; and response to methylmercury. Predicted to localize to the mitochondrial outer membrane. Human ortholog(s) of this gene implicated in ataxia telangiectasia; colon adenocarcinoma; and precursor lymphoblastic lymphoma/leukemia. Is expressed in several structures, including digestive system; eye; heart; immune system; and ovary. Orthologous to human BAX (BCL2 associated X, apoptosis regulator).
Genome Resources: Alliance (1),  Gene:58081 (1),  Ensembl(GRCz11):ENSDARG00000020623 (2)
GENE EXPRESSION
All Expression Data: 39 figures from 34 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66309]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6041 Point Mutation Unknown Premature Stop ENU
sa14515 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-baxa N/A 1
    MO2-baxa N/A 4
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH baxa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute lymphocytic leukemia Alliance T-cell acute lymphoblastic leukemia, somatic 613065
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    DISEASE ASSOCIATED WITH baxa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of apoptotic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function channel activity (more)
    GO Terms (all 15)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript baxa-203 (1)    Ensembl 861
    mRNA baxa-201 (1)    Ensembl 1981
    baxa-204 (1)    Ensembl 1720
    ncRNA baxa-002 (1)    Ensembl 676
    baxa-003 (1)    Ensembl 734
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM baxa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(amh-LOXP-CMV:NPT-HcRed-LOXP-baxb,baxa) amhCMV baxabaxbHcRedNPT Danio rerio 1 2
    Tg(zp3.2-LOXP-CMV:NPT-HcRed-LOXP-baxb,baxa) CMVzp3.2 baxabaxbHcRedNPT Danio rerio 1 2
    MARKER RELATIONSHIPS
    baxa Contained in: [BAC] DKEY-260C8 (1) (order this)
    baxa Encodes: [EST] fc50b10, fj16e01 (1)
    [cDNA] MGC:66309 (1) (order this), MGC:192165 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131562 (1) 1960 bp
    Genomic GenBank:CR388062 (1) 153088 bp
    Select Tool
    Polypeptide UniProtKB:I3ITC2 (1) 197 aa
    Sequence Clusters UniGene:78968 (1)
    Sequence Information (all 21)
    ORTHOLOGY for baxa ( Chr: 3 )
    CITATIONS (203)