FIGURE

FIGURE 10

ID

ZDB-FIG-210518-36

Publication

Wiweger et al., 2021 - npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease

Other Figures

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FIGURE 10

Treatment with 2-hydroxypropyl-β-cyclodextrin increased the expression of genes that are related to inflammation and Ca²⁺ homeostasis in 5 dpf npc2^–/– larvae to wildtype levels. Scatterplots show the normalized expression of selected genes in untreated larvae (A) and larvae that were treated with 2 mM 2HPβCD (B) at 5 dpf. Each circle corresponds to one zebrafish. The 18S ribosomal gene was used as a reference. The experiments were performed in triplicate. ***p < 0.001, **p < 0.01, *p < 0.05.

Expression Data

Genes:	apoea capn2a cldnk il1b lgals3a mbpa mcu mpeg1.1 mpz nfkb2 olig1 ppp3ca
Fish:	TL npc2.1^{waw302/waw302} (TL)
Condition:	chemical treatment: beta-cyclodextrin
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	npc2.1^{waw302/waw302} (TL)
Condition:	chemical treatment: beta-cyclodextrin
Observed In:	whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.