Gene
cldnk
- ID
- ZDB-GENE-040801-201
- Name
- claudin k
- Symbol
- cldnk Nomenclature History
- Previous Names
-
- claudin 31
- cldn31a (1)
- zgc:91878
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in integument and nervous system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91878 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Claudin | Claudin, conserved site | PMP-22/EMP/MP20/Claudin |
|---|---|---|---|---|---|
| UniProtKB:Q6DBT9 | InterPro | 216 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(cldnk:GAL4) |
|
| 1 | (23) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-285G17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:91878 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192208 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003464 (1) | 1270 nt | ||
| Genomic | GenBank:BX682554 (2) | 61290 nt | ||
| Polypeptide | UniProtKB:Q6DBT9 (1) | 216 aa |
No data available
- Spencer, S.A., Suárez-Pozos, E., Verdugo, J.S., Wang, H., Afshari, F.S., Guo, L., Manam, S., Yasuda, D., Ortega, A., Lister, J.A., Ishii, S., Zhang, Y., Fuss, B. (2022) Lysophosphatidic acid signaling via LPA6 : a negative modulator of developmental oligodendrocyte maturation. Journal of neurochemistry. 163(6):478-499
- Wiweger, M., Majewski, L., Adamek-Urbanska, D., Wasilewska, I., Kuznicki, J. (2021) npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease. Frontiers in Cellular Neuroscience. 15:647860
- Nagarajan, B., Harder, A., Japp, A., Häberlein, F., Mingardo, E., Kleinert, H., Yilmaz, Ö., Zoons, A., Rau, B., Christ, A., Kubitscheck, U., Eiberger, B., Sandhoff, R., Eckhardt, M., Hartmann, D., Odermatt, B. (2019) CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch. Glia. 68(3):509-527
- Phan, V., Cox, D., Cipriani, S., Spendiff, S., Buchkremer, S., O'Connor, E., Horvath, R., Goebel, H.H., Hathazi, D., Lochmüller, H., Straka, T., Rudolf, R., Weis, J., Roos, A. (2018) SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human. Neurobiology of disease. 124:218-229
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Shen, K., Sidik, H., Talbot, W.S. (2016) The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia. Cell Reports. 14(3):547-59
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kearns, C.A., Ravanelli, A.M., Cooper, K., Appel, B. (2015) Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:14861-71
- Sidik, H., Talbot, W.S. (2015) A zinc finger protein that regulates oligodendrocyte specification, migration, and myelination in zebrafish. Development (Cambridge, England). 142(23):4119-28
- Wheeler, N.A., Lister, J.A., Fuss, B. (2015) The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:11399-414
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