Gene

mcu

ID
ZDB-GENE-061013-24
Name
mitochondrial calcium uniporter
Symbol
mcu Nomenclature History
Previous Names
  • ccdc109a
  • wu:fi24a01
  • zgc:153607 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Enables identical protein binding activity. Acts upstream of or within several processes, including calcium import into the mitochondrion; convergent extension involved in gastrulation; and mitochondrial calcium ion homeostasis. Predicted to be located in membrane and mitochondrion. Predicted to be part of uniplex complex. Predicted to be active in mitochondrial inner membrane. Is expressed in brain; head; liver; pericardial region; and visceral fat. Used to study cardiomyopathy. Orthologous to human MCU (mitochondrial calcium uniporter).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mcu Human Ortholog
No data available
Associated With mcu Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006769 Calcium uniporter protein, C-terminal
Family IPR039055 MCU family
Domain Details Per Protein
Protein Length Calcium uniporter protein, C-terminal MCU family
UniProtKB:F1QT29 376
UniProtKB:Q08BI9 376
UniProtKB:K0A5D6 376
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations