Gene
mcu
- ID
- ZDB-GENE-061013-24
- Name
- mitochondrial calcium uniporter
- Symbol
- mcu Nomenclature History
- Previous Names
-
- ccdc109a
- wu:fi24a01
- zgc:153607 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Acts upstream of or within several processes, including calcium import into the mitochondrion; convergent extension involved in gastrulation; and mitochondrial calcium ion homeostasis. Predicted to be located in membrane and mitochondrion. Predicted to be part of uniplex complex. Predicted to be active in mitochondrial inner membrane. Is expressed in brain; head; liver; pericardial region; and visceral fat. Used to study cardiomyopathy. Orthologous to human MCU (mitochondrial calcium uniporter).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cardiomyopathy | mcula2434/la2434 | standard conditions | Langenbacher et al., 2020 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calcium uniporter protein, C-terminal | MCU family |
|---|---|---|---|
|
UniProtKB:K0A5D6
|
376 | ||
|
UniProtKB:Q08BI9
|
376 |
Interactions and Pathways
No data available
Plasmids