Gene

apoea

ID
ZDB-GENE-010724-18
Name
apolipoprotein Ea
Symbol
apoea Nomenclature History
Previous Names
  • ApoE-1 (1)
  • im:7036787
  • wu:fb69a05
  • zgc:110064
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Is predicted to enable lipid binding activity. Involved in several processes, including cholesterol catabolic process; lipoprotein catabolic process; and positive regulation of nitric-oxide synthase activity. Acts upstream of or within lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region. Predicted to be part of intermediate-density lipoprotein particle. Is expressed in brain; female organism; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Hwang et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With apoea Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
age related macular degeneration 1 Alliance {?Macular degeneration, age-related} 603075
Alzheimer's disease 2 Alliance Alzheimer disease 2 104310
Alzheimer's disease 3 Alliance {?Alzheimer disease, protection against, due to APOE3-Christchurch} 607822
hyperlipoproteinemia type III Alliance Hyperlipoproteinemia, type III 617347
hyperlipoproteinemia type III Alliance {Coronary artery disease, severe, susceptibility to} 617347
sea-blue histiocytosis Alliance Sea-blue histiocyte disease 269600
Lipoprotein glomerulopathy 611771
Associated With apoea Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000074 Apolipoprotein A/E
Domain Details Per Protein
Protein Length Apolipoprotein A/E
UniProtKB:A0A0R4IQ18 74
UniProtKB:Q503V2 269
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations