Gene
lgals3a
- ID
- ZDB-GENE-030131-7667
- Name
- lectin, galactoside binding soluble 3a
- Symbol
- lgals3a Nomenclature History
- Previous Names
-
- lgals3
- fb13c09
- fk60g08
- si:ch211-67f24.5
- wu:fb13c09
- wu:fk60g08 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable IgE binding activity; disaccharide binding activity; and laminin binding activity. Predicted to be involved in several processes, including leukocyte chemotaxis; negative regulation of extrinsic apoptotic signaling pathway; and positive regulation of calcium ion import. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in extracellular region. Predicted to be part of spliceosomal complex. Predicted to be active in several cellular components, including extracellular space; immunological synapse; and nucleus. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Wiweger et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa44794 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8N7UTJ9 | InterPro | 368 |
| UniProtKB:A0AB13A476 | InterPro | 368 |
| UniProtKB:A0AB13AAJ1 | InterPro | 243 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lgals3a-201
(1)
|
Ensembl | 999 nt | ||
| mRNA |
lgals3a-202
(1)
|
Ensembl | 1,283 nt | ||
| mRNA |
lgals3a-204
(1)
|
Ensembl | 1,170 nt | ||
| ncRNA |
lgals3a-003
(1)
|
Ensembl | 869 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-67F24 | ZFIN Curated Data | |
| Encodes | EST | fb13c09 | ||
| Encodes | EST | fk60g08 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001386796 (1) | 1850 nt | ||
| Genomic | GenBank:BX927407 (2) | 123739 nt | ||
| Polypeptide | UniProtKB:A0A8N7UTJ9 (1) | 368 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515
- Wiweger, M., Majewski, L., Adamek-Urbanska, D., Wasilewska, I., Kuznicki, J. (2021) npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease. Frontiers in Cellular Neuroscience. 15:647860
- Zhong, Z., Yang, L., Zhang, Y.E., Xue, Y., He, S. (2016) Correlated expression of retrocopies and parental genes in zebrafish. Molecular genetics and genomics : MGG. 291(2):723-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
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