Gene

lgals3a

ID

ZDB-GENE-030131-7667

Name

lectin, galactoside binding soluble 3a

Symbol

lgals3a Nomenclature History

Previous Names

lgals3
fb13c09
fk60g08
si:ch211-67f24.5
wu:fb13c09
wu:fk60g08 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable IgE binding activity; disaccharide binding activity; and laminin binding activity. Predicted to be involved in several processes, including leukocyte chemotaxis; negative regulation of extrinsic apoptotic signaling pathway; and positive regulation of calcium ion import. Predicted to act upstream of or within RNA processing; cell differentiation; and innate immune response. Predicted to be located in extracellular region. Predicted to be part of spliceosomal complex. Predicted to be active in several cellular components, including extracellular space; immunological synapse; and nucleus. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Wiweger et al., 2021

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lgals3a Human Ortholog

No data available

Associated With lgals3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001079	Galectin, carbohydrate recognition domain
Family	IPR044156	Galectin-like
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8N7UTJ9	InterPro	368
UniProtKB:A0AB13A476	InterPro	368
UniProtKB:A0AB13AAJ1	InterPro	243

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lgals3a-201 (1) Ensembl	Ensembl	999 nt	Select Tool ZFIN BLAST
mRNA	lgals3a-202 (1) Ensembl	Ensembl	1,283 nt	Select Tool ZFIN BLAST
mRNA	lgals3a-204 (1) Ensembl	Ensembl	1,170 nt	Select Tool ZFIN BLAST
ncRNA	lgals3a-003 (1) Ensembl	Ensembl	869 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations