ZFIN is now using GRCz12tu for Genomic Data
Gene
nfkb2
- ID
- ZDB-GENE-030131-6701
- Name
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
- Symbol
- nfkb2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within angiogenesis and cholesterol homeostasis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including cardiac ventricle; female organism; liver; male organism; and retina. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| common variable immunodeficiency 10 | Alliance | Immunodeficiency, common variable, 10 | 615577 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030492 | Rel homology domain, conserved site |
| Domain | IPR000488 | Death domain |
| Domain | IPR002909 | IPT domain |
| Domain | IPR011539 | Rel homology domain, DNA-binding domain |
| Domain | IPR030497 | Nuclear factor NF-kappa-B, p100 subunit, RHD domain, N-terminal |
| Domain | IPR032397 | Rel homology dimerisation domain |
| Domain | IPR033926 | NFkappaB IPT domain |
| Family | IPR000451 | NF-kappa-B/Dorsal |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Homologous_superfamily | IPR037059 | Rel homology domain (RHD), DNA-binding domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Death domain | Death-like domain superfamily | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | NF-kappa-B/Dorsal | NFkappaB IPT domain | Nuclear factor NF-kappa-B, p100 subunit, RHD domain, N-terminal | p53-like transcription factor, DNA-binding domain superfamily | Rel homology dimerisation domain | Rel homology domain, conserved site | Rel homology domain, DNA-binding domain | Rel homology domain (RHD), DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q0II00 | InterPro | 902 | |||||||||||||||
| UniProtKB:A0A8M2B350 | InterPro | 896 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers