ZFIN ID: ZDB-GENE-030131-6701
Gene Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Gene Symbol: nfkb2    Nomenclature History

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Previous Names: p100/p52 (1), p100 (1), wu:fa03b02 (1), zgc:136693

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in angiogenesis and cholesterol homeostasis. Predicted to localize to I-kappaB/NF-kappaB complex; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2).
Genome Resources: Alliance (1),  Gene:415100 (1),  Ensembl(GRCz11):ENSDARG00000038687 (1)
GENE EXPRESSION
All Expression Data: 8 figures from 8 publications
Wild-type Stages, Structures: Cleavage:32-cell (1.75h-2.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
DISEASE ASSOCIATED WITH nfkb2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
common variable immunodeficiency Alliance Immunodeficiency, common variable, 10 615577
DISEASE ASSOCIATED WITH nfkb2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process angiogenesis (more)
Cellular Component cytoplasm (more)
Molecular Function DNA binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nfkb2-201 (1)    Ensembl 849
nfkb2-202 (1)    Ensembl 840
nfkb2-203 (1)    Ensembl 3458
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nfkb2 No data available
MARKER RELATIONSHIPS
nfkb2 Contained in: [BAC] CH211-134M17 (1), CH211-150I13 (1)
nfkb2 Encodes: [EST] fa03b02
[cDNA] MGC:136693 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001001840 (1) 3809 nt
Genomic GenBank:BX005174 (1) 178371 nt
Select Tool
Polypeptide UniProtKB:Q0II00 (1) 902 aa
Sequence Information (all 24)
ORTHOLOGY for nfkb2 ( Chr: 13 )
CITATIONS (77)