Gene
olig1
- ID
- ZDB-GENE-050107-2
- Name
- oligodendrocyte transcription factor 1
- Symbol
- olig1 Nomenclature History
- Previous Names
-
- Oligo1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity. Acts upstream of or within oligodendrocyte development. Predicted to be active in nucleus. Is expressed in central nervous system; oligodendrocyte; and trunk. Orthologous to human OLIG1 (oligodendrocyte transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-olig1 | (2) | |
| CRISPR2-olig1 | (2) | |
| CRISPR3-olig1 | (2) | |
| CRISPR4-olig1 | (2) | |
| CRISPR5-olig1 | (2) | |
| CRISPR6-olig1 | (2) | |
| CRISPR7-olig1 | (2) | |
| CRISPR8-olig1 | (2) | |
| CRISPR9-olig1 | (2) | |
| CRISPR10-olig1 | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic helix-loop-helix transcription factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|---|
| UniProtKB:Q5QJR2 | InterPro | 235 | |||
| UniProtKB:A8WIQ7 | InterPro | 235 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(olig1:cfp-NTR) |
|
| 1 | Xiao et al., 2022 | |
| Tg(olig1:dnmet-IRES-EGFP,cryaa:EGFP) |
|
| 1 | Ali et al., 2021 | |
| Tg(olig1:EGFP-CAAX) |
|
| 1 | Bromley-Coolidge et al., 2024 | |
| Tg(olig1:GCaMP6m) |
|
| 1 | Marisca et al., 2020 | |
| Tg(olig1:KALTA4) |
|
| 1 | Marisca et al., 2020 | |
| Tg(olig1:MA-EYFP) |
|
| 1 | (3) | |
| Tg(olig1:mEGFP) |
|
| 1 | (3) | |
| Tg(olig1:mScarlet) |
|
| 1 | Brennan et al., 2024 | |
| Tg(olig1:mScarlet-CAAX) |
|
| 1 | (2) | |
| Tg(olig1:NLS-Cerulean) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-165B19 | ZFIN Curated Data | |
| Contains | STS | zfish37251-2157c04.p1c | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020796 (1) | 708 nt | ||
| Genomic | GenBank:BX571724 (1) | 174709 nt | ||
| Polypeptide | UniProtKB:A8WIQ7 (1) | 235 aa |
- Brennan, E.J., Monk, K.R., Li, J. (2024) A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin. Neural Development. 19:1414
- Bromley-Coolidge, S., Iruegas, D., Appel, B. (2024) Cspg4 sculpts oligodendrocyte precursor cell morphology. Differentiation; research in biological diversity. 140:100819100819
- Deng, J., Wang, Y., Hu, M., Lin, J., Li, Q., Liu, C., Xu, X. (2022) Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism. Frontiers in molecular neuroscience. 15:904935
- Vagionitis, S., Auer, F., Xiao, Y., Almeida, R.G., Lyons, D.A., Czopka, T. (2022) Clusters of neuronal neurofascin prefigure the position of a subset of nodes of Ranvier along individual central nervous system axons in vivo. Cell Reports. 38:110366
- Xiao, Y., Petrucco, L., Hoodless, L.J., Portugues, R., Czopka, T. (2022) Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling. Nature Neuroscience. 25(3):280-284
- Ali, M.F., Latimer, A.J., Wang, Y., Hogenmiller, L., Fontenas, L., Isabella, A.J., Moens, C.B., Yu, G., Kucenas, S. (2021) Met is required for oligodendrocyte progenitor cell migration in Danio rerio. G3 (Bethesda). 11(10):
- Scott, K., O'Rourke, R., Winkler, C.C., Kearns, C.A., Appel, B. (2021) Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations. Developmental Biology. 479:37-50
- Wiweger, M., Majewski, L., Adamek-Urbanska, D., Wasilewska, I., Kuznicki, J. (2021) npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease. Frontiers in Cellular Neuroscience. 15:647860
- Keefe, M.D., Soderholm, H.E., Shih, H.Y., Stevenson, T.J., Glaittli, K.A., Bowles, D.M., Scholl, E., Colby, S., Merchant, S., Hsu, E.W., Bonkowsky, J.L. (2020) Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response. eLIFE. 9:
- Marisca, R., Hoche, T., Agirre, E., Hoodless, L.J., Barkey, W., Auer, F., Castelo-Branco, G., Czopka, T. (2020) Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation. Nature Neuroscience. 23(3):363-374
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