Gene
mbpa
- ID
- ZDB-GENE-030128-2
- Name
- myelin basic protein a
- Symbol
- mbpa Nomenclature History
- Previous Names
-
- mbp
- cb274 (1)
- fj33b11
- wu:fj33b11
- wu:fq15b02
- zgc:136630
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of myelin sheath. Located in myelin sheath and plasma membrane. Is expressed in several structures, including EVL; male organism; nervous system; otic vesicle; and periderm. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 196 figures from 114 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb274 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mbpa | (2) | |
| CRISPR2-mbpa | (2) | |
| CRISPR3-mbpa | (2) | |
| CRISPR4-mbpa | (2) | |
| MO1-mbpa | N/A | Boczonadi et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000548 | Myelin basic protein |
Domain Details Per Protein
| Protein | Additional Resources | Length | Myelin basic protein |
|---|---|---|---|
| UniProtKB:F8W3W8 | InterPro | 95 | |
| UniProtKB:I3ITP3 | InterPro | 137 | |
| UniProtKB:A0A8M9P2C7 | InterPro | 130 | |
| UniProtKB:F8W2M5 | InterPro | 91 | |
| UniProtKB:Q5I2C7 | InterPro | 88 | |
| UniProtKB:F8W3A0 | InterPro | 79 | |
| UniProtKB:E7F0U0 | InterPro | 100 | |
| UniProtKB:F8W3M5 | InterPro | 125 | |
| UniProtKB:F8W3V8 | InterPro | 107 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mbpa-201
(1)
|
Ensembl | 1,719 nt | ||
| mRNA |
mbpa-202
(1)
|
Ensembl | 1,610 nt | ||
| mRNA |
mbpa-203
(1)
|
Ensembl | 761 nt | ||
| mRNA |
mbpa-205
(1)
|
Ensembl | 581 nt | ||
| mRNA |
mbpa-206
(1)
|
Ensembl | 861 nt | ||
| mRNA |
mbpa-207
(1)
|
Ensembl | 497 nt | ||
| mRNA |
mbpa-208
(1)
|
Ensembl | 737 nt | ||
| mRNA |
mbpa-209
(1)
|
Ensembl | 761 nt | ||
| mRNA |
mbpa-210
(1)
|
Ensembl | 560 nt | ||
| mRNA |
mbpa-211
(1)
|
Ensembl | 869 nt | ||
| ncRNA |
mbpa-006
(1)
|
Ensembl | 1,043 nt |
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(1mbp:EGFP) |
|
| 1 | (17) | |
| Tg2(mbpa:Dendra2) |
|
| 1 | (3) | |
| Tg2(mbpa:Dendra2-UTR) |
|
| 1 | Torvund-Jensen et al., 2018 | |
| Tg2(mbpa:EGFP-CAAX) |
|
| 1 | (2) | |
| Tg2(mbpa:mCherry-CAAX) |
|
| 1 | Hughes et al., 2020 | |
| Tg(mbpa:Citrine) |
|
| 1 | Ashikawa et al., 2016 | |
| Tg(mbpa:Dendra2) |
|
| 1 | Torvund-Jensen et al., 2018 | |
| Tg(mbpa:Dendra2-CAAX) |
|
| 1 | (3) | |
| Tg(mbpa:Dendra2-UTR) |
|
| 1 | Torvund-Jensen et al., 2018 | |
| Tg(mbpa:EGFP-CAAX) |
|
| 1 | Strachan et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-207C1 | ZFIN Curated Data | |
| Encodes | EST | cb274 | Thisse et al., 2001 | |
| Encodes | EST | fj33a07 | ||
| Encodes | EST | fj33b11 | ZFIN Curated Data | |
| Encodes | EST | fq15b02 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:136630 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020483 (1) | 1733 nt | ||
| Genomic | GenBank:CU856623 (2) | 62435 nt | ||
| Polypeptide | UniProtKB:I3ITP3 (1) | 137 aa |
- Bhattarai, P., Gunasekaran, T.I., Belloy, M.E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E.M., Hupalo, D.N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., Nuriel, T., Ertekin-Taner, N., Teich, A.F., Dickson, D.W., Holley, S., Greicius, M., Dalgard, C.L., Zody, M., Mayeux, R., Kizil, C., Vardarajan, B.N. (2024) Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathologica. 147:7070
- Iyer, H., Talbot, W.S. (2024) Chloride transporter ClC-7 is essential for phagocytic clearance by microglia. Journal of Cell Science. 137(4):
- Raas, Q., Wood, A., Stevenson, T.J., Swartwood, S., Liu, S., Kannan, R.M., Kannan, S., Bonkowsky, J.L. (2024) Generation and characterization of a zebrafish gain-of-function ACOX1 Mitchell disease model. Frontiers in pediatrics. 12:13268861326886
- Saraswathy, V.M., Zhou, L., Mokalled, M.H. (2024) Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair. Nature communications. 15:68086808
- Accogli, A., Lin, S.J., Severino, M., Kim, S.H., Huang, K., Rocca, C., Landsverk, M., Zaki, M., Al-Maawali, A., Srinivasan, V.M., Al-Thihli, K., Schaefer, G.B., Davis, M., Tonduti, D., Doneda, C., Marten, L.M., Mühlhausen, C., Gomez, M., Lamantea, E., Mena, R., Nizon, M., Procaccio, V., Begtrup, A., Telegrafi, A., Cui, H., Schulz, H.L., Mohr, J., Biskup, S., Loos, M.A., Aráoz, H.V., Salpietro, V., Keppen, L.D., Chitre, M., Petree, C., Raymond, L., Vogt, J., Swayer, L.B., Basinger, A.A., Pedersen, S.V., Pearson, T.S., Grange, D.K., Lingapp, L., McDunnah, P., Horvath, R., Cogne, B., Isidor, B., Hahn, A., Gripp, K., Jafarnejad, S.M., Ostergaard, E., Prada, C.E., Ghezzi, D., Gowda, V.K., Taylor, R.W., Sonenberg, N., Houlden, H., Sissler, M., Varshney, G.K., Maroofian, R. (2023) Clinical, neuroradiological and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder. Genetics in medicine : official journal of the American College of Medical Genetics. 25(11):100938
- Bouchard, E.L., Meireles, A.M., Talbot, W.S. (2023) Oligodendrocyte development and myelin sheath formation are regulated by the antagonistic interaction between the Rag-Ragulator complex and TFEB. Glia. 72(2):289-299
- Kaiyrzhanov, R., Rad, A., Lin, S.J., Bertoli-Avella, A., Kallemeijn, W.W., Godwin, A., Zaki, M.S., Huang, K., Lau, T., Petree, C., Efthymiou, S., Ghayoor Karimiani, E., Hempel, M., Normand, E.A., Rudnik-Schöneborn, S., Schatz, U.A., Baggelaar, M.P., Ilyas, M., Sultan, T., Alvi, J.R., Ganieva, M., Fowler, B., Aanicai, R., Akay Tayfun, G., Al Saman, A., Alswaid, A., Amiri, N., Asilova, N., Shotelersuk, V., Yeetong, P., Azam, M., Babaei, M., Bahrami Monajemi, G., Mohammadi, P., Samie, S., Banu, S.H., Basto, J.P., Kortüm, F., Bauer, M., Bauer, P., Beetz, C., Garshasbi, M., Hameed Issa, A., Eyaid, W., Ahmed, H., Hashemi, N., Hassanpour, K., Herman, I., Ibrohimov, S., Abdul-Majeed, B.A., Imdad, M., Isrofilov, M., Kaiyal, Q., Khan, S., Kirmse, B., Koster, J., Lourenço, C.M., Mitani, T., Moldovan, O., Murphy, D., Najafi, M., Pehlivan, D., Rocha, M.E., Salpietro, V., Schmidts, M., Shalata, A., Mahroum, M., Talbeya, J.K., Taylor, R.W., Vazquez, D., Vetro, A., Waterham, H.R., Zaman, M., Schrader, T.A., Chung, W.K., Guerrini, R., Lupski, J.R., Gleeson, J., Suri, M., Jamshidi, Y., Bhatia, K.P., Vona, B., Schrader, M., Severino, M., Guille, M., Tate, E.W., Varshney, G.K., Houlden, H., Maroofian, R. (2023) Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. Brain : a journal of neurology. 147(4):1436-1456
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Shi, L., Wang, Z., Li, Y., Song, Z., Yin, W., Hu, B. (2023) Deletion of the chd7 Hinders Oligodendrocyte Progenitor Cell Development and Myelination in Zebrafish. International Journal of Molecular Sciences. 24(17):
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
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