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Research
General Information
ZIRC
ZFIN ID: ZDB-FIG-180801-4
Wang et al., 2017 - Epigenetic regulation of left-right asymmetry by DNA methylation. The EMBO journal   36(20):2987-2997 Full text @ EMBO J.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage: 75%-epiboly
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: 75%-epiboly to Prim-15

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
cdh1 s870Tg standard conditions 75%-epiboly whole organism RTPCR
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism RTPCR
dkk1b s870Tg standard conditions 75%-epiboly whole organism RTPCR
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism RTPCR
dusp6 s870Tg standard conditions 75%-epiboly whole organism RTPCR
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism RTPCR
fgf8a s870Tg standard conditions 75%-epiboly whole organism RTPCR
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism RTPCR
gata5 s870Tg standard conditions 75%-epiboly whole organism RTPCR
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism RTPCR
id3 s870Tg standard conditions 75%-epiboly whole organism RTPCR
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism RTPCR
lft2 s870Tg standard conditions 75%-epiboly forerunner cell group ISH
75%-epiboly whole organism RTPCR
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly forerunner cell group ISH
75%-epiboly whole organism RTPCR
pitx2 s870Tg standard conditions 75%-epiboly whole organism RTPCR
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism RTPCR
tbxta s870Tg standard conditions 75%-epiboly whole organism RTPCR
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism RTPCR
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly forerunner cell group decreased amount, abnormal
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly forerunner cell group lft2 expression increased amount, abnormal
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism cdh1 expression decreased amount, abnormal
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism fgf8a expression decreased amount, abnormal
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism gata5 expression decreased amount, abnormal
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism dkk1b expression decreased amount, abnormal
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism tbxta expression decreased amount, abnormal
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism id3 expression decreased amount, abnormal
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism pitx2 expression decreased amount, abnormal
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism dusp6 expression decreased amount, abnormal
s870Tg + MO4-dnmt1 standard conditions 75%-epiboly whole organism lft2 expression increased amount, abnormal
s870Tg + MO4-dnmt1 + MO4-lft2 standard conditions 75%-epiboly forerunner cell group amount, ameliorated
twu34Tg + MO4-dnmt1 standard conditions Prim-15 determination of heart left/right asymmetry process quality, abnormal
Prim-15 heart looping process quality, abnormal
twu34Tg + MO4-dnmt1 + MO4-lft2 standard conditions Prim-15 determination of heart left/right asymmetry process quality, ameliorated
Prim-15 heart looping process quality, ameliorated
Full text @ EMBO J.