Gene
lft2
- ID
- ZDB-GENE-990630-11
- Name
- lefty2
- Symbol
- lft2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within heart field specification and mesoderm development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastodisc; cardiovascular system; central nervous system; hypoblast; and mesoderm. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to several human genes including LEFTY2 (left-right determination factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 119 figures from 93 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb720 (33 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lft2 | He et al., 2020 | |
| MO1-lft2 | N/A | (5) |
| MO2-lft2 | N/A | (5) |
| MO3-lft2 | N/A | Choi et al., 2007 |
| MO4-lft2 | N/A | Wang et al., 2017 |
| MO5-lft2 | N/A | Stock et al., 2022 |
| TALEN1-lft2 | Bassett et al., 2014 | |
| TALEN2-lft2 | (5) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR003942 | Left- Right determination factor |
| Family | IPR015615 | Transforming growth factor-beta-related |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Left- Right determination factor | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W6I7 | InterPro | 362 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(lft2:GAL4FF) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-236P5 | ZFIN Curated Data | |
| Encodes | EST | cb720 | Thisse et al., 2001 | |
| Encodes | EST | fe38b03 | ||
| Encodes | cDNA | MGC:114024 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130961 (1) | 1315 nt | ||
| Genomic | GenBank:BX248131 (1) | 162685 nt | ||
| Polypeptide | UniProtKB:Q9W6I7 (1) | 362 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | LEFTY2 | 1 | Amino acid sequence comparison (1) |
- Deng, Z., Ran, Q., Chang, W., Li, C., Li, B., Huang, S., Huang, J., Zhang, K., Li, Y., Liu, X., Liang, Y., Guo, Z., Huang, S. (2024) Cdon is essential for organ left-right patterning by regulating dorsal forerunner cells clustering and Kupffer's vesicle morphogenesis. Frontiers in cell and developmental biology. 12:14297821429782
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Wang, P., Shi, W., Liu, S., Shi, Y., Jiang, X., Li, F., Chen, S., Sun, K., Xu, R. (2024) ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 51(9):934-946
- Ali, R.Q., Meyer-Miner, A., David-Rachel, M., Lee, F.J.H., Wilkins, B.J., Karpen, S.J., Ciruna, B., Ghanekar, A., Kamath, B.M. (2023) Loss of a cilia-associated gene, pkd1l1, causes biliary defects in zebrafish: Implications for Biliary Atresia Splenic Malformation. Disease models & mechanisms. 16(10):
- Rochon, E.R., Xue, J., Mohammed, M.S., Smith, C., Hay-Schmidt, A., DeMartino, A.W., Clark, A., Xu, Q., Lo, C.W., Tsang, M., Tejero, J., Gladwin, M.T., Corti, P. (2023) Cytoglobin regulates NO-dependent cilia motility and organ laterality during development. Nature communications. 14:83338333
- Kuhn, T., Landge, A.N., Mörsdorf, D., Coßmann, J., Gerstenecker, J., Čapek, D., Müller, P., Gebhardt, J.C.M. (2022) Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model. Nature communications. 13:6101
- Liu, M., Zou, X., Fu, M., Bai, X., Zhao, Y., Chen, X., Wang, X., Wang, P., Huang, S. (2022) Mild cold stress specifically disturbs clustering movement of DFCs and sequential organ left-right patterning in zebrafish. Frontiers in cell and developmental biology. 10:952844
- Liu, S., Wei, W., Wang, P., Liu, C., Jiang, X., Li, T., Li, F., Wu, Y., Chen, S., Sun, K., Xu, R. (2022) LOF variants identifying candidate genes of laterality defects patients with congenital heart disease. PLoS Genetics. 18:e1010530e1010530
- Ouyang, S., Qin, W.M., Niu, Y.J., Ding, Y.H., Deng, Y. (2022) An EGFP Knock-in Zebrafish Experimental Model Used in Evaluation of the Amantadine Drug Safety During Early Cardiogenesis. Frontiers in cardiovascular medicine. 9:839166
- Stock, J., Kazmar, T., Schlumm, F., Hannezo, E., Pauli, A. (2022) A self-generated Toddler gradient guides mesodermal cell migration. Science advances. 8:eadd2488
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