Gene

dusp6

ID
ZDB-GENE-030613-1
Name
dual specificity phosphatase 6
Symbol
dusp6 Nomenclature History
Previous Names
  • etID14116.25 (1)
  • Mkp3 (2)
  • wu:fd99d09 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Exhibits phosphoprotein phosphatase activity. Involved in several processes, including negative regulation of cardiac muscle tissue regeneration; regulation of endodermal cell fate specification; and regulation of signal transduction. Predicted to localize to cytosol. Is expressed in several structures, including brain; fin; germ ring; gonad; and head. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6).
Genome Resources
Note
None
Expression
All Expression Data
63 figures from 42 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dusp6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypogonadotropic hypogonadism 19 with or without anosmia Alliance Hypogonadotropic hypogonadism 19 with or without anosmia 615269
Associated With dusp6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000340 Dual specificity phosphatase, catalytic domain
Domain IPR000387 Tyrosine specific protein phosphatases domain
Domain IPR001763 Rhodanese-like domain
Domain IPR020422 Dual specificity protein phosphatase domain
Family IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Homologous_superfamily IPR036873 Rhodanese-like domain superfamily
Domain Details Per Protein
Protein Length Dual specificity phosphatase, catalytic domain Dual specificity protein phosphatase domain Mitogen-activated protein (MAP) kinase phosphatase Protein-tyrosine phosphatase-like Rhodanese-like domain Rhodanese-like domain superfamily Tyrosine specific protein phosphatases domain
UniProtKB:Q7T2L8 382
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-dusp6 monoclonal IgG1 , k Mouse
  • IHC
  • WB
Sigma-Aldrich
4
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations