ZFIN ID: ZDB-GENE-990415-72
Gene Name: fibroblast growth factor 8a
Gene Symbol: fgf8a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: fgf-8, fgf8, ace, acerebellar, cb110 (1), etID309886.13 (1), id:ibd5031, wu:fb73a06

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have fibroblast growth factor receptor binding activity and growth factor activity. Involved in several processes, including animal organ development; determination of bilateral symmetry; and nervous system development. Localizes to the extracellular space and lysosome. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Is expressed in several structures, including germ ring; head; mesoderm; nervous system; and neural keel. Orthologous to human FGF8 (fibroblast growth factor 8).
Genome Resources: Alliance (1),  Gene:30538 (1),  Ensembl(GRCz11):ENSDARG00000003399 (1)
GENE EXPRESSION
All Expression Data: 304 figures from 240 publications
Directly Submitted Expression Data: 7 figures (100 images) from Thisse et al., 2001 [cb110]
  4 figures (5 images) from Kudoh et al., 2001 [ibd5031]
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fgf8a_unspecified Unspecified Unknown Unknown
la012336Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2694 Point Mutation Unknown Premature Stop ENU
    ti282a Point Mutation Donor Splice Site of Intron 2 Splice Site, Exon Loss of Exon 2, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • x15 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE
    Data: 62 figures from 40 publications
    Observed in:
    DISEASE ASSOCIATED WITH fgf8a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypogonadotropic hypogonadism 6 with or without anosmia Alliance Hypogonadotropic hypogonadism 6 with or without anosmia 612702
    DISEASE ASSOCIATED WITH fgf8a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of dorsal identity (more)
    Cellular Component extracellular space (more)
    Molecular Function fibroblast growth factor receptor binding (more)
    GO Terms (all 62)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR002209 Fibroblast growth factor family
    Family IPR028249 Fibroblast growth factor 8
    Homologous_superfamily IPR008996 Cytokine IL1/FGF
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fgf8a-201 (1)    Ensembl 2238
    fgf8a-202 (1)    Ensembl 600
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM fgf8a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:fgf8a) hsp70l fgf8a Danio rerio 1 10
    Tg(nkx2.5:fgf8a-GFP) nkx2.5 fgf8aGFP Danio rerio 1 3
    Tg(UAS:fgf8a-UTRnanos3) UAS fgf8ananos3UTR Danio rerio 1 1
    Tg1(fgf8a:EGFP) fgf8a EGFP Danio rerio 1 3
    Tg1(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg1(hsp70l:fgf8a) hsp70l fgf8a Danio rerio 1 18
    Tg2(fgf8a:EGFP) fgf8a EGFP Danio rerio 2 3
    Tg2(fgf8a:GFP) fgf8a GFP Danio rerio 1 2
    Tg3(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg4(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg5(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg6(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg7(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg8(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg9(fgf8a:GFP) fgf8a GFP Danio rerio 1 2
    Tg10(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg11(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg12(fgf8a:GFP) fgf8a GFP Danio rerio 1 2
    Tg13(fgf8a:GFP) fgf8a GFP Danio rerio 1 2
    Tg14(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg15(fgf8a:GFP) fgf8a GFP Danio rerio 1 2
    Tg16(fgf8a:GFP) fgf8a GFP Danio rerio 1 2
    Tg17(fgf8a:GFP) fgf8a GFP Danio rerio 1 4
    Tg18(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg20(fgf8a:GFP) fgf8a GFP Danio rerio 1 2
    Tg21(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    Tg22(fgf8a:GFP) fgf8a GFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    fgf8a Contained in: [BAC] CH211-194I8 (1)
    fgf8a Encodes: [EST] cb110 (1), fb73a06 (1), ibd5031 (1)
    [cDNA] MGC:101652 (1), MGC:192193 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131281 (1) 2146 nt
    Genomic GenBank:CR925797 (1) 65727 nt
    Select Tool
    Polypeptide UniProtKB:A0A0B5JPZ5 (1) 210 aa
    Sequence Information (all 34)
    ORTHOLOGY for fgf8a ( Chr: 13 )
    CITATIONS (530)