Gene

fgf8a

ID
ZDB-GENE-990415-72
Name
fibroblast growth factor 8a
Symbol
fgf8a Nomenclature History
Previous Names
  • fgf-8
  • fgf8
  • ace
  • acerebellar
  • cb110 (1)
  • etID309886.13 (1)
  • id:ibd5031
  • wu:fb73a06
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including animal organ development; determination of bilateral symmetry; and nervous system development. Localizes to extracellular space and lysosome. Is expressed in several structures, including germ ring; head; mesoderm; nervous system; and neural keel. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (fibroblast growth factor 8).
Genome Resources
Note
None
Expression
All Expression Data
313 figures from 247 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
66 figures from 43 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fgf8a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypogonadotropic hypogonadism 6 with or without anosmia Alliance Hypogonadotropic hypogonadism 6 with or without anosmia 612702
Associated With fgf8a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002209 Fibroblast growth factor family
Family IPR028249 Fibroblast growth factor 8
Homologous_superfamily IPR008996 Cytokine IL1/FGF
Domain Details Per Protein
Protein Length Cytokine IL1/FGF Fibroblast growth factor 8 Fibroblast growth factor family
UniProtKB:Q0E9Y8 199
UniProtKB:A0A0B5JPZ5 210
UniProtKB:A2CF52 199
UniProtKB:O42278 210
UniProtKB:O57341 210
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations