Gene
ntn1a
- ID
- ZDB-GENE-990415-169
- Name
- netrin 1a
- Symbol
- ntn1a Nomenclature History
- Previous Names
-
- net1a (1)
- ntn2
- net2
- zgc:136732
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including circulatory system development; closure of optic fissure; and neuron differentiation. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in basement membrane. Is expressed in several structures, including brain; head; optic cup; optic vesicle; and somite. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human NTN1 (netrin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Mirror movements 4 | 618264 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Galactose-binding-like domain superfamily | Laminin/Netrin Extracellular Matrix | Laminin, N-terminal | Laminin-type EGF domain | Netrin domain | Netrin module, non-TIMP type | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QA53 | InterPro | 553 | |||||||
| UniProtKB:O42140 | InterPro | 603 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Yao, H., Shen, Y., Song, Z., Han, A., Chen, X., Zhang, Y., Hu, B. (2024) Rab11 promotes single Mauthner cell axon regeneration in vivo through axon guidance molecule Ntng2b. Experimental neurology. 374:114715
- Dang, P., Barnes, D.T., Cheng, R.P., Xu, A., Ji Moon, Y., Sripad Kodukula, S., Raper, J.A. (2022) Netrins and netrin receptors are essential for normal targeting of sensory axons in the zebrafish olfactory bulb. Neuroscience. 508:19-29
- Hoffmann, S., Schmitteckert, S., Raedecke, K., Rheinert, D., Diebold, S., Roeth, R., Weiss, B., Granzow, M., Niesler, B., Griesbeck, A., Eckstein, V., Zimmermann, W.H., Just, S., Rappold, G.A. (2021) Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control. Biochimica et biophysica acta. Gene regulatory mechanisms. 1864(4-5):194702
- Knickmeyer, M.D., Mateo, J.L., Heermann, S. (2021) BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish. International Journal of Molecular Sciences. 22(9):
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Hardy, H., Prendergast, J.G., Patel, A., Dutta, S., Trejo-Reveles, V., Kroeger, H., Yung, A.R., Goodrich, L.V., Brooks, B., Sowden, J.C., Rainger, J. (2019) Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion. eLIFE. 8:
- Jiang, Y., Zhang, S., Zhang, X., Li, N., Zhang, Q., Guo, X., Chi, X., Tong, M. (2019) Peptidomic analysis of zebrafish embryos exposed to polychlorinated biphenyls and their impact on eye development. Ecotoxicology and environmental safety. 175:164-172
- Li, D., Zhu, G., Lou, S., Ma, L., Zhang, C., Pan, Y., Wang, L. (2019) The functional variant of NTN1 contributes to the risk of nonsyndromic cleft lip with or without cleft palate. European journal of human genetics : EJHG. 28(4):453-460
- Richardson, R., Owen, N., Toms, M., Young, R.M., Tracey-White, D., Moosajee, M. (2019) Transcriptome profiling of zebrafish optic fissure fusion. Scientific Reports. 9:1541
- Turner, K.J., Hoyle, J., Valdivia, L.E., Cerveny, K.L., Hart, W., Mangoli, M., Geisler, R., Rees, M., Houart, C., Poole, R.J., Wilson, S.W., Gestri, G. (2019) Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. PLoS One. 14:e0211073
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