Fig. 3
- ID
- ZDB-FIG-110224-9
- Publication
- Dal-Pra et al., 2011 - FoxA transcription factors are essential for the development of dorsal axial structures
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FoxA2 and FoxA3 are required for the maintenance but not for the induction of axial mesoderm. (A–J) Expression at 80% epiboly of the chordamesoderm marker twist2 (A–E) and the paraxial mesoderm marker myf5 (F–J) in FoxA2 (B and G) or FoxA3 (C and H) and FoxA2–FoxA3 (D, E, I, and J) morphants. twist2 and myf5 expressions are identical to wild-type (A and F) in FoxA2 morphants or slightly affected in FoxA3 morphants. In double FoxA2–FoxA3 morphants, axial mesoderm is narrower (D) or almost absent (E), while paraxial mesoderm is dorsally extended (I) or partially fused along the dorsal midline (J). (K–N) flh expression domain in FoxA2–FoxA3 morphants is not affected at the shield stage (L) and is narrower at 80% epiboly (N) compared to wild-type (K and M). Dorsal views, anterior up except (K and L) lateral views. |
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| Stage Range: | Shield to 75%-epiboly |
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| Stage Range: | Shield to 75%-epiboly |
Reprinted from Developmental Biology, 350(2), Dal-Pra, S., Thisse, C., and Thisse, B., FoxA transcription factors are essential for the development of dorsal axial structures, 484-495, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.