FIGURE

Figure 5

ID

ZDB-FIG-240229-194

Publication

Zhang et al., 2024 - Nomo1 deficiency causes autism-like behavior in zebrafish

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Figure 5

Loss-of-function of nomo1 affected neurodevelopment in larval zebrafish.

(A, B) EGFP labeled GABAergic inhibitory neurons and dsRed labeled glutamatergic excitatory neurons at 48 hpf and 3 dpf of WT and nomo1^−/−. Scale bar=1 mm. (C, D) RFP labeled neuro progenitors at 3 dpf and 6 dpf of WT and nomo1^−/−. Scale bar=1 mm. (E, F) Quantitative analysis of fluorescent signal (biological replicates, n = 4). (G) The relative expression level of neurological genes in nomo1^−/− brain at 3 mpf (N = 4 × 5 animals per group). (H) The relative expression level of apoptosis genes in nomo1^−/− brain at 3 mpf (N = 4 × 5 animals per group). Data information: Data are analyzed using unpaired t test and presented as the means ± SEM. ^*P < 0.05 and ^**P < 0.01, ^****P < 0.0001. Source data are available online for this figure.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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