Gene

egr2b

ID
ZDB-GENE-980526-283
Name
early growth response 2b
Symbol
egr2b Nomenclature History
Previous Names
  • egr2 (1)
  • cb427 (1)
  • id:ibd5073 (1)
  • krox-20
  • krox20
  • krx20
  • wu:fb71h10
  • zgc:92210
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic organ development and nervous system development. Predicted to localize to nuclear chromatin. Is expressed in several structures, including nervous system; neural crest; neural keel; neural plate; and neural rod. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2).
Genome Resources
Note
None
Expression
All Expression Data
536 figures from 373 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With egr2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease type 1D Alliance Charcot-Marie-Tooth disease, type 1D 607678
Charcot-Marie-Tooth disease type 3 Alliance Dejerine-Sottas disease 145900
Charcot-Marie-Tooth disease type 4E Alliance Hypomyelinating neuropathy, congenital, 1 605253
Associated With egr2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Domain IPR021849 Early growth response, N-terminal
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Early growth response, N-terminal Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:Q66HY5 412
UniProtKB:E9QC39 232
UniProtKB:Q05159 412
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations