ZFIN ID: ZDB-GENE-980526-112
Gene Name: ISL LIM homeobox 1
Gene Symbol: isl1    Nomenclature History

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Previous Names: Isl-1 (1), islet-1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including atrial cardiac muscle cell differentiation; neuron differentiation; and pancreas development. Localizes to nucleus. Is expressed in several structures, including mesoderm; nervous system; neural rod; pancreatic system; and pericardial region. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1).
Genome Resources: Alliance (1),  Gene:30147 (1),  Ensembl(GRCz11):ENSDARG00000004023 (2)
GENE EXPRESSION
All Expression Data: 277 figures from 198 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2004 [MGC:73031]
  6 figures (12 images) from Thisse et al., 2005 [eu243]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
rw436 Point Mutation Unknown Cryptic Acceptor Splice Site, Frameshift, Premature Stop ENU
sa29 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-isl1 N/A 1
MO2-isl1 N/A 9
MO3-isl1 N/A 8
MO4-isl1 N/A 5
MO5-isl1 N/A 1
MO6-isl1 N/A 1
DISEASE ASSOCIATED WITH isl1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH isl1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process exocrine pancreas development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 26)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA isl1-201 (1)    Ensembl 2303
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-isl monoclonal IgG1 Mouse IHC Developmental Studies Hybridoma Bank
25
Ab5-isl1 monoclonal IgG1 Mouse IHC Developmental Studies Hybridoma Bank
2
Ab1-isl1 polyclonal IgG Rabbit IHC 2
Ab2-isl monoclonal IgG2b Mouse IHC Developmental Studies Hybridoma Bank
119
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM isl1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(2xNRSE-isl1-Mmu.Fos:KALTA4,5xUAS-E1B:GAP-YFP-2A-NTR) E1Bisl1UAS KALTA4NTRYFP Danio rerioMus musculus 2 3
Tg(2XNRSE-isl1-Mmu.Fos:KALTA4,5xUAS-E1B:GAP-YFP-2A-NTR_T41Q_N71S_F124T) E1Bisl1NRSEUAS 2AGAPKALTA4NTRYFP Danio rerioMus musculus 2 1
Tg(Hsa.ISL1-isl1:GFP) isl1 GFP Danio rerioHomo sapiens 1 3
Tg(hsp70l:isl1) hsp70l isl1 Danio rerio 1 3
Tg(isl1-gata2a:GAL4-VP16) gata2aisl1 GAL4VP16 Danio rerio 1 2
Tg(isl1-hsp70l:dncdh2-mCherry) hsp70lisl1 cdh2mCherry Danio rerio 2 1
Tg(isl1-hsp70l:dnplxna4-GFP) hsp70lisl1 GFPplxna4 Danio rerio 3 5
Tg(isl1-hsp70l:GFP) hsp70lisl1 GFP Danio rerio 3 10
tg(isl1-hsp70l:lifeact-egfp) hsp70lisl1 EGFPLIFEACT Danio rerio 1 1
Tg(isl1-hsp70l:MA-TFP) hsp70lisl1 MATFP Danio rerio 1 1
Tg(isl1-hsp70l:trpm7-EGFP) hsp70lisl1 EGFPtrpm7 Danio rerio 0 1
Tg(isl1-hsp70l:Xla.Dvl2-GFP) hsp70lisl1 GFP Danio rerioXenopus laevis 1 1
Tg(isl1-Mmu.Fos:KALTA4,5xUAS-E1B:GAP-YFP-2A-NTR) E1Bisl1UAS KALTA4NTRYFP Danio rerioMus musculus 1 2
Tg(isl1:EGFP-CAAX) isl1 CAAXEGFP Danio rerio 1 1
Tg(isl1:GAL4,14xUAS:KikGR,14xUAS:Mmu.Wlds) isl1UAS GAL4KikGR Danio rerioMus musculus 2 2
Tg(isl1:GAL4-VP16,4xUAS:Cat.TRPA1-TagRFP) isl1UAS GAL4TagRFPVP16 Crotalus atroxDanio rerio 1 3
Tg(isl1:GAL4-VP16,4xUAS:Rno.TRPV1-TagRFP) isl1UAS GAL4TagRFPVP16 Danio rerioRattus norvegicus 0 1
Tg(isl1:GAL4-VP16,14xUAS:EGFP) isl1UAS EGFPGAL4VP16 Danio rerio 1 2
Tg(isl1:GAL4-VP16,14xUAS:Kaede) isl1UAS GAL4KaedeVP16 Danio rerio 1 6
Tg(isl1:GAL4-VP16,14xUAS:KikGR) isl1UAS GAL4KikGRVP16 Danio rerio 1 3
Tg(isl1:GAL4-VP16,14xUAS:Tomato) isl1UAS GAL4TomatoVP16 Danio rerio 1 1
Tg(isl1:GAL4-VP16,UAS:EGFP) isl1UAS EGFPGAL4VP16 Danio rerio 1 19
Tg(isl1:GAL4-VP16,UAS:RFP) isl1UAS GAL4RFPVP16 Danio rerio 1 12
Tg(isl1:GAL4VP16,4xUAS:Rno.Trpv1-TagRFP) isl1UAS GAL4TagRFPVP16 Danio rerioRattus norvegicus 1 3
Tg(isl1:GFP) isl1 GFP Danio rerio 1 191
Tg(isl1:LEXA-VP16,LEXAOP-Tomato) isl1 Tomato Danio rerio 1 3
Tg(isl1:NTR-mCherry) isl1 mCherryNTR Danio rerio 1 1
Tg2(isl1-hsp70l:GFP) hsp70lisl1 GFP Danio rerio 1 3
Tg2(isl1:GAL4-VP16,14xUAS:KikGR) isl1UAS GAL4KikGRVP16 Danio rerio 1 2
Tg2(isl1:GFP) isl1 GFP Danio rerio 1 14
Tg4(isl1:GFP) isl1 GFP Danio rerio 1 8
TgBAC(isl1:GAL4FF) isl1 GAL4FF Danio rerio 2 5
TgBAC(isl1:GFP) isl1 GFP Danio rerio 1 1
MARKER RELATIONSHIPS
isl1 Contained in: [BAC] CH211-219F7 (1)
isl1 Contains: [SNP] rs3727897 (1)
isl1 Encodes: [EST] eu243 (1)
[cDNA] MGC:73031 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_130962 (1) 2275 nt
Genomic GenBank:AL954694 (1) 111431 nt
Select Tool
Polypeptide UniProtKB:P53405 (1) 349 aa
Sequence Information (all 20)
ORTHOLOGY for isl1 ( Chr: 5 )
CITATIONS (399)