ZFIN ID: ZDB-GENE-990415-174
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Gene Name: neurogenin 1
Gene Symbol: neurog1    Nomenclature History

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Previous Names: neurod3, neurogenin1, neurogenin (1), ngr1, cb260 (1), chunp6899, neurogenic differentiation 3 (1), ngn1, Zath4c (1), zNgn1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have E-box binding activity and chromatin binding activity. Involved in nervous system development; neuromast development; and olfactory placode development. Predicted to localize to the nucleus. Is expressed in several structures, including ectoderm; nervous system; neural keel; neural plate; and neural tube. Orthologous to several human genes including NEUROG1 (neurogenin 1).
Genome Resources: Alliance (1),  Gene:30239 (1),  Ensembl(GRCz11):ENSDARG00000056130 (1)
GENE EXPRESSION
All Expression Data: 227 figures from 147 publications
Directly Submitted Expression Data: 6 figures (37 images) from Thisse et al., 2001 [cb260]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1059Tg Transgenic Insertion 3' UTR Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-neurog1 N/A 14
    MO2-neurog1 N/A 3
    MO3-neurog1 N/A 4
    MO4-neurog1 N/A 12
    MO5-neurog1 N/A 4
    MO6-neurog1 N/A 4
    MO8-neurog1 N/A 3
    MO9-neurog1 N/A 1
    PHENOTYPE
    Data: 25 figures from 16 publications
    Observed in:
    DISEASE ASSOCIATED WITH neurog1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH neurog1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process forebrain neuron development (more)
    Cellular Component nucleus (more)
    Molecular Function protein binding (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Family IPR032653 Neurogenin-1
    Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA neurog1-201 (1)    Ensembl 1393
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-neurog1 polyclonal Mouse IHC Abcam plc
    		1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM neurog1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-3.1neurog1:GFP) neurog1 GFP Danio rerio 1 22
    Tg(-3.1neurog1:GFP-CAAX) neurog1 GFP Danio rerio 1 5
    Tg(-3.1neurog1:GFP-rab7a) neurog1 GFP,  rab7a Danio rerio 1 1
    Tg(-3.1neurog1:GFP-rab7a_K157N) neurog1 GFP,  rab7a Danio rerio 1 1
    Tg(-3.1neurog1:GFP-rab7a_L129F) neurog1 GFP,  rab7a Danio rerio 1 1
    Tg(-3.1neurog1:TagRFP-CAAX) neurog1 TagRFP Danio rerio 1 4
    Tg(-3.4neurog1:GFP) neurog1 GFP Danio rerio 1 12
    Tg(-8.4neurog1:GFP) neurog1 GFP Danio rerio 1 49
    Tg(-8.4neurog1:nRFP) neurog1 RFP Danio rerio 1 18
    Tg(-17.0neurog1:EGFP) neurog1 EGFP Danio rerio 1 20
    Tg(hsp70l:neurog1) hsp70l neurog1 Danio rerio 1 6
    Tg(neurog1:DsRed) neurog1 DsRed Danio rerio 1 8
    Tg(neurog1:GFP) neurog1 GFP Danio rerio 1 2
    Tg2(hsp70l:neurog1) hsp70l neurog1 Danio rerio 1 2
    TgBAC(neurog1:GFP) neurog1 GFP Danio rerio 1 2
    TgBAC(neurog1:LOXP-Tomato-LOXP-GFP) neurog1 GFP,  Tomato Danio rerio 1 3
    MARKER RELATIONSHIPS
    neurog1 Contained in: [BAC] DKEY-171N3 (1) (order this)
    neurog1 Encodes: [EST] cb260 (1) (order this)
    [cDNA] MGC:65737 (1), MGC:76812 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131041 (1) 1399 nt
    Select Tool
    Genomic GenBank:BX571940 (1) 179550 nt
    Select Tool
    Polypeptide UniProtKB:O42606 (1) 208 aa
    Select Tool
    Sequence Information (all 22)
    ORTHOLOGY for neurog1 ( Chr: 14 )
    CITATIONS (334)